Abstract
Accurate assessment of electrocardiographic intervals is crucial for routine patient care and clinical research. This assessment requires well-characterized references ranges. This article provides a complete set of reference ranges for numerical electrocardiogram (ECG) parameters (PR, QRS, QTc intervals, and heart rate). The reference ranges are derived from a large clinical trial patient population using a standardized ECG acquisition and analysis system (N = 13,039). The reference ranges are stratified by important prognostic factors: age, sex, and overall ECG evaluation at baseline (normal or abnormal). The proposed referance ranges may be useful for patient management and data analyses in clinical drug development. In addition, the article provides a QT correction formula to correct the QT interval for heart rate. This QT correction formula was shown to be superior to the Bazett and Fridericia corrections in a clinical trial population in the ability to minimize the correction between QT and RR.
| Original language | English |
|---|---|
| Pages (from-to) | 395-405 |
| Number of pages | 11 |
| Journal | Drug Information Journal |
| Volume | 39 |
| Issue number | 4 |
| State | Published - 2005 |
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Keywords
- Clinical trials
- Electrocardiograms
- QT interval
- Reference ranges
ASJC Scopus subject areas
- Health Informatics
- Public Health, Environmental and Occupational Health
- Pharmacology
- Nursing(all)
Cite this
Electrocardiogram reference ranges derived from a standardized clinical trial population. / Dmitrienko, Alexei A.; Sides, Gregory D.; Winters, Kenneth J.; Kovacs, Richard; Rebhun, Dawn M.; Bloom, John C.; Groh, William; Eisenberg, Paul R.
In: Drug Information Journal, Vol. 39, No. 4, 2005, p. 395-405.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electrocardiogram reference ranges derived from a standardized clinical trial population
AU - Dmitrienko, Alexei A.
AU - Sides, Gregory D.
AU - Winters, Kenneth J.
AU - Kovacs, Richard
AU - Rebhun, Dawn M.
AU - Bloom, John C.
AU - Groh, William
AU - Eisenberg, Paul R.
PY - 2005
Y1 - 2005
N2 - Accurate assessment of electrocardiographic intervals is crucial for routine patient care and clinical research. This assessment requires well-characterized references ranges. This article provides a complete set of reference ranges for numerical electrocardiogram (ECG) parameters (PR, QRS, QTc intervals, and heart rate). The reference ranges are derived from a large clinical trial patient population using a standardized ECG acquisition and analysis system (N = 13,039). The reference ranges are stratified by important prognostic factors: age, sex, and overall ECG evaluation at baseline (normal or abnormal). The proposed referance ranges may be useful for patient management and data analyses in clinical drug development. In addition, the article provides a QT correction formula to correct the QT interval for heart rate. This QT correction formula was shown to be superior to the Bazett and Fridericia corrections in a clinical trial population in the ability to minimize the correction between QT and RR.
AB - Accurate assessment of electrocardiographic intervals is crucial for routine patient care and clinical research. This assessment requires well-characterized references ranges. This article provides a complete set of reference ranges for numerical electrocardiogram (ECG) parameters (PR, QRS, QTc intervals, and heart rate). The reference ranges are derived from a large clinical trial patient population using a standardized ECG acquisition and analysis system (N = 13,039). The reference ranges are stratified by important prognostic factors: age, sex, and overall ECG evaluation at baseline (normal or abnormal). The proposed referance ranges may be useful for patient management and data analyses in clinical drug development. In addition, the article provides a QT correction formula to correct the QT interval for heart rate. This QT correction formula was shown to be superior to the Bazett and Fridericia corrections in a clinical trial population in the ability to minimize the correction between QT and RR.
KW - Clinical trials
KW - Electrocardiograms
KW - QT interval
KW - Reference ranges
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UR - http://www.scopus.com/inward/citedby.url?scp=27744576792&partnerID=8YFLogxK
M3 - Article
VL - 39
SP - 395
EP - 405
JO - Drug Information Journal
JF - Drug Information Journal
SN - 0092-8615
IS - 4
ER -