Electrodermal Activity in Young Adults at Genetic Risk for Affective Disorder

Theodore P. Zahn, John Nurnberger, Wade H. Berrettini

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Low electrodermal activity has been proposed as a trait marker for affective disorder. We attempted to determine if low electrodermal activity could be a genetic marker by testing subjects at genetic risk for affective disorder. High-risk subjects, 22 offspring of a parent with bipolar affective disorder, and 27 lowrisk controls 15 to 25 years old had skin conductance recorded bilaterally during rest periods, presentation of 10 nonsignal tones, and performance of reaction-time and mental arithmetic tasks. There were no significant differences in skin conductance levels under any condition or in the frequency or amplitude of orienting responses to nonsignal tones. During task periods high-risk subjects showed significantly greater electrodermal activity that was lateralized to the left hand. Self-rated depression was higher in the high-risk group during task periods. The results show that low electrodermal activity is not a likely genetic marker for affective disorder but suggest that autonomic hyperresponsivity, atypically lateralized information processing, and depressive affect occur during mild stress in persons at risk for the development of affective disorder.

Original languageEnglish (US)
Pages (from-to)1120-1124
Number of pages5
JournalArchives of General Psychiatry
Volume46
Issue number12
DOIs
StatePublished - 1989

Fingerprint

Mood Disorders
Young Adult
Genetic Markers
Skin
Genetic Testing
Automatic Data Processing
Bipolar Disorder
Hand
Affective
Genetic Risk
Young Adults
Depression

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Electrodermal Activity in Young Adults at Genetic Risk for Affective Disorder. / Zahn, Theodore P.; Nurnberger, John; Berrettini, Wade H.

In: Archives of General Psychiatry, Vol. 46, No. 12, 1989, p. 1120-1124.

Research output: Contribution to journalArticle

Zahn, Theodore P. ; Nurnberger, John ; Berrettini, Wade H. / Electrodermal Activity in Young Adults at Genetic Risk for Affective Disorder. In: Archives of General Psychiatry. 1989 ; Vol. 46, No. 12. pp. 1120-1124.
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