Electrophysiologic testing of antiarrhythmic agents

Douglas P. Zipes, E. N. Prystowsky, J. J. Heger

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The purpose of these studies is to illustrate that the time of drug administration in experimental animals subjected to coronary artery occlusion is an important influence on the myocardial distribution of the drug as well as its electrophysiologic and arrhythmogenic effects. Also, because several drugs have active metabolites, some studies must be done after oral administration. Finally, electrophysiologic testing to determine drug efficacy may give misieading results with some drugs.

Original languageEnglish (US)
Pages (from-to)610-615
Number of pages6
JournalAmerican Heart Journal
Issue number4 PART 2
StatePublished - Apr 1982

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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