Electrophysiologic testing of antiarrhythmic agents

Douglas P. Zipes, E. N. Prystowsky, J. J. Heger

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The purpose of these studies is to illustrate that the time of drug administration in experimental animals subjected to coronary artery occlusion is an important influence on the myocardial distribution of the drug as well as its electrophysiologic and arrhythmogenic effects. Also, because several drugs have active metabolites, some studies must be done after oral administration. Finally, electrophysiologic testing to determine drug efficacy may give misieading results with some drugs.

Original languageEnglish
Pages (from-to)610-615
Number of pages6
JournalAmerican Heart Journal
Volume103
Issue number4 PART 2
DOIs
StatePublished - 1982

Fingerprint

Pharmaceutical Preparations
Coronary Occlusion
Oral Administration
Coronary Vessels

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Zipes, D. P., Prystowsky, E. N., & Heger, J. J. (1982). Electrophysiologic testing of antiarrhythmic agents. American Heart Journal, 103(4 PART 2), 610-615. https://doi.org/10.1016/0002-8703(82)90465-3

Electrophysiologic testing of antiarrhythmic agents. / Zipes, Douglas P.; Prystowsky, E. N.; Heger, J. J.

In: American Heart Journal, Vol. 103, No. 4 PART 2, 1982, p. 610-615.

Research output: Contribution to journalArticle

Zipes, DP, Prystowsky, EN & Heger, JJ 1982, 'Electrophysiologic testing of antiarrhythmic agents', American Heart Journal, vol. 103, no. 4 PART 2, pp. 610-615. https://doi.org/10.1016/0002-8703(82)90465-3
Zipes, Douglas P. ; Prystowsky, E. N. ; Heger, J. J. / Electrophysiologic testing of antiarrhythmic agents. In: American Heart Journal. 1982 ; Vol. 103, No. 4 PART 2. pp. 610-615.
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