Electrophysiological characteristics of rodent myocardium damaged by adrenaline

Robert F. Gilmour, Douglas P. Zipes

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Summary: Myocardial cell injury was produced in rats and Guinea pigs by injecting 3.0 mg·kg-1 1-adrenaline subcutaneously. Ventricular myocardium removed from animals 24 h after the injection exhibited marked electrophysiological alterations when studied in vitro. These alterations included: (1) reduced resting membrane potential, action potential amplitude and duration, and dV/dt; (2) conduction disturbances such as delay, unidirectional block, summation and inhibition; (3) abnormal automatic activity including triggered sustained rhythmic activity and post-overdrive acceleration. Conduction disturbances were affected by stimulus intensity, duration, rate and site of pacing. Isoprenaline (10-7mol·litre-1) improved conduction. Automatic activity was modified by changes in entrance and exit block and depolarising or hyperpolarising current pulses. These data indicate that diverse abnormal electrophysiological alterations occur in myocardium damaged by adrenaline.

Original languageEnglish
Pages (from-to)582-589
Number of pages8
JournalCardiovascular Research
Volume14
Issue number10
DOIs
StatePublished - Oct 1980

Fingerprint

Myocardium
Conduction
Epinephrine
Rodentia
Disturbance
Isoproterenol
Membrane Potentials
Action Potentials
Rats
Guinea pig
Guinea Pigs
Animals
Membrane Potential
Action Potential
Membranes
Summation
Injections
Injection
Wounds and Injuries
Cell

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Electrophysiological characteristics of rodent myocardium damaged by adrenaline. / Gilmour, Robert F.; Zipes, Douglas P.

In: Cardiovascular Research, Vol. 14, No. 10, 10.1980, p. 582-589.

Research output: Contribution to journalArticle

Gilmour, Robert F. ; Zipes, Douglas P. / Electrophysiological characteristics of rodent myocardium damaged by adrenaline. In: Cardiovascular Research. 1980 ; Vol. 14, No. 10. pp. 582-589.
@article{5c98b70ba0424c4d8e58ca20fb2f5a9b,
title = "Electrophysiological characteristics of rodent myocardium damaged by adrenaline",
abstract = "Summary: Myocardial cell injury was produced in rats and Guinea pigs by injecting 3.0 mg·kg-1 1-adrenaline subcutaneously. Ventricular myocardium removed from animals 24 h after the injection exhibited marked electrophysiological alterations when studied in vitro. These alterations included: (1) reduced resting membrane potential, action potential amplitude and duration, and dV/dt; (2) conduction disturbances such as delay, unidirectional block, summation and inhibition; (3) abnormal automatic activity including triggered sustained rhythmic activity and post-overdrive acceleration. Conduction disturbances were affected by stimulus intensity, duration, rate and site of pacing. Isoprenaline (10-7mol·litre-1) improved conduction. Automatic activity was modified by changes in entrance and exit block and depolarising or hyperpolarising current pulses. These data indicate that diverse abnormal electrophysiological alterations occur in myocardium damaged by adrenaline.",
author = "Gilmour, {Robert F.} and Zipes, {Douglas P.}",
year = "1980",
month = "10",
doi = "10.1093/cvrese/14.10.582",
language = "English",
volume = "14",
pages = "582--589",
journal = "Cardiovascular Research",
issn = "0008-6363",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Electrophysiological characteristics of rodent myocardium damaged by adrenaline

AU - Gilmour, Robert F.

AU - Zipes, Douglas P.

PY - 1980/10

Y1 - 1980/10

N2 - Summary: Myocardial cell injury was produced in rats and Guinea pigs by injecting 3.0 mg·kg-1 1-adrenaline subcutaneously. Ventricular myocardium removed from animals 24 h after the injection exhibited marked electrophysiological alterations when studied in vitro. These alterations included: (1) reduced resting membrane potential, action potential amplitude and duration, and dV/dt; (2) conduction disturbances such as delay, unidirectional block, summation and inhibition; (3) abnormal automatic activity including triggered sustained rhythmic activity and post-overdrive acceleration. Conduction disturbances were affected by stimulus intensity, duration, rate and site of pacing. Isoprenaline (10-7mol·litre-1) improved conduction. Automatic activity was modified by changes in entrance and exit block and depolarising or hyperpolarising current pulses. These data indicate that diverse abnormal electrophysiological alterations occur in myocardium damaged by adrenaline.

AB - Summary: Myocardial cell injury was produced in rats and Guinea pigs by injecting 3.0 mg·kg-1 1-adrenaline subcutaneously. Ventricular myocardium removed from animals 24 h after the injection exhibited marked electrophysiological alterations when studied in vitro. These alterations included: (1) reduced resting membrane potential, action potential amplitude and duration, and dV/dt; (2) conduction disturbances such as delay, unidirectional block, summation and inhibition; (3) abnormal automatic activity including triggered sustained rhythmic activity and post-overdrive acceleration. Conduction disturbances were affected by stimulus intensity, duration, rate and site of pacing. Isoprenaline (10-7mol·litre-1) improved conduction. Automatic activity was modified by changes in entrance and exit block and depolarising or hyperpolarising current pulses. These data indicate that diverse abnormal electrophysiological alterations occur in myocardium damaged by adrenaline.

UR - http://www.scopus.com/inward/record.url?scp=0019127307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019127307&partnerID=8YFLogxK

U2 - 10.1093/cvrese/14.10.582

DO - 10.1093/cvrese/14.10.582

M3 - Article

C2 - 7214393

AN - SCOPUS:0019127307

VL - 14

SP - 582

EP - 589

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

IS - 10

ER -