Electrophysiological effects of ethmozin on canine myocardium

Rodolphe Ruffy, Leonid V. Rozenshtraukh, Victor Elharrar, Douglas P. Zipes

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Summary: The electrophysiological effects of ethmozin on canine myocardium were studied in anaesthetised open-chest animals and in superfused Purkinje fibres. The drug did not change spontaneous sinus node cycle length and atrioventricular conduction time when selectively injected into the sinus nodal artery and into the posterior septal artery, respectively. Right and left ventricular diastolic excitability threshold and refractory period were increased following the intravenous administration of ethmozin, 4 mg·kg-1. Ethmozin (3 to 5 mg·kg -1 i.v.) markedly increased conduction delay in the ischaemic zone of the left ventricle during acute coronary artery occlusion. This change was associated with the development of ventricular fibrillation in 50% of the dogs.In vitro, ethmozin 1 × 10-3 and 1 × 10 -2 g·litre-1 shortened Purkinje fibres' action potential duration. At 1 × 10 -2 g·litre-1, ethmozin decreased the rate of rise of phase 0, and slightly reduced action potential amplitude.

Original languageEnglish
Pages (from-to)354-363
Number of pages10
JournalCardiovascular Research
Volume13
Issue number6
DOIs
StatePublished - Jun 1979

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Ruffy, R., Rozenshtraukh, L. V., Elharrar, V., & Zipes, D. P. (1979). Electrophysiological effects of ethmozin on canine myocardium. Cardiovascular Research, 13(6), 354-363. https://doi.org/10.1093/cvrese/13.6.354