Elevated Levels of Plasma Prorenin (Inactive Renin) in Diabetic and Nondiabetic Patients with Autonomic Dysfunction

Robert I. Misbin, Maria B. Grant, Mark S. Pecker, Steven A. Atlas

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

We measured plasma inactive renin (prorenin) levels in 46 diabetic patients, 4 nondiabetic patients with idiopathic autonomic dysfunction, and 115 normal subjects. Plasma inactive renin levels were normal in the diabetic patients who had no complications (n = 6)and in those with microvascular disease (n = 8) who did not have coexistent autonomic dysfunction. Plasma inactive renin was either grossly elevated or in the upper limit of the normal range in diabetic patients with autonomic dysfunction (n = 18). No correlation was found between plasma inactive renin and glycemic control, as measured byhemoglobin A1c. High plasma inactive renin levels were also found in the 4 nondiabetic patients with idiopathic autonomic dysfunction. These data suggest that increased plasma inactive renin levels in diabetic patients are a consequence of coexistent autonomic dysfunction. This finding is consistent with other evidencethat suggests autonomic regulation of the processing of prorenin to renin within the kidney.

Original languageEnglish (US)
Pages (from-to)964-968
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume64
Issue number5
DOIs
StatePublished - May 1987

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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