Elevated levels of plasma prorenin (inactive renin) in diabetic and nondiabetic patients with autonomic dysfunction

R. I. Misbin, M. B. Grant, M. S. Pecker, S. A. Atlas

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We measured plasma inactive renin (prorenin) levels in 46 diabetic patients, 4 nondiabetic patients with idiopathic autonomic dysfunction, and 115 normal subjects. Plasma inactive renin levels were normal in the diabetic patients who had no complications (n = 6) and in those with microvascular disease (n = 8) who did not have coexistent autonomic dysfunction. Plasma inactive renin was either grossly elevated or in the upper limit of the normal range in diabetic patients with autonomic dysfunction (n = 18). No correlation was found between plasma inactive renin and glycemic control, as measured by hemoglobin A(1c). High plasma inactive renin levels were also found in the 4 nondiabetic patients with idiopathic autonomic dysfunction. These data suggest that increased plasma inactive renin levels in diabetic patients are a consequence of coexistent autonomic dysfunction. This finding is consistent with other evidence that suggests autonomic regulation of the processing of prorenin to renin within the kidney.

Original languageEnglish (US)
Pages (from-to)964-968
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume64
Issue number5
StatePublished - 1987
Externally publishedYes

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Renin
Plasmas
Hemoglobin A
Reference Values
Kidney
Processing

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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Elevated levels of plasma prorenin (inactive renin) in diabetic and nondiabetic patients with autonomic dysfunction. / Misbin, R. I.; Grant, M. B.; Pecker, M. S.; Atlas, S. A.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 64, No. 5, 1987, p. 964-968.

Research output: Contribution to journalArticle

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