Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure

D. A. Tonetti, M. Morrow, N. Kidwai, A. Gupta, Sunil Badve

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We previously reported that stable transfection of protein kinase C alpha (PKCα) into T47D human breast cancer cells results in tamoxifen (TAM)-resistant turnout growth. Relevance of PKCα expression in clinical specimens was determined by comparing PKCα expression in tumours from patients exhibiting disease recurrence with patients remaining disease-free following TAM treatment. Our results suggest that PKCα expression may predict TAM treatment failure.

Original languageEnglish
Pages (from-to)1400-1402
Number of pages3
JournalBritish Journal of Cancer
Volume88
Issue number9
DOIs
StatePublished - May 6 2003

Fingerprint

Protein Kinase C-alpha
Tamoxifen
Treatment Failure
Transfection
Breast Neoplasms
Recurrence
Growth
Neoplasms

Keywords

  • Breast cancer
  • Protein kinase C alpha
  • Tamoxifen resistance

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure. / Tonetti, D. A.; Morrow, M.; Kidwai, N.; Gupta, A.; Badve, Sunil.

In: British Journal of Cancer, Vol. 88, No. 9, 06.05.2003, p. 1400-1402.

Research output: Contribution to journalArticle

Tonetti, D. A. ; Morrow, M. ; Kidwai, N. ; Gupta, A. ; Badve, Sunil. / Elevated protein kinase C alpha expression may be predictive of tamoxifen treatment failure. In: British Journal of Cancer. 2003 ; Vol. 88, No. 9. pp. 1400-1402.
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