Elevated serum levels of IL-8 in patients with HIV infection

T. Matsumoto, T. Miike, R. P. Nelson, W. L. Trudeau, R. F. Lockey, J. Yodoi

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Serum levels of IL-8 were determined in HIV-infected individuals and the results were compared with those for HIV- controls. The IL-8 levels were measured by an ELISA with a MoAb and a polyclonal antibody to recombinant IL-8. The means and 95% confidence intervals of IL-8 in sera of 36 HIV-infected individuals and 32 matched controls were 275 and 216-349 pg/ml, and 8 and 4-14 pg/ml, respectively, showing a 34-fold increase in IL-8 in the circulation of HIV-infected individuals. This increase does not appear to be related to the disease state, infection or systemic medical agents. This finding suggests the possible involvement of IL-8 in the pathogenesis of HIV-induced disease.

Original languageEnglish (US)
Pages (from-to)149-151
Number of pages3
JournalClinical and Experimental Immunology
Volume93
Issue number2
StatePublished - Jan 1 1993

    Fingerprint

Keywords

  • AIDS
  • HIV infection
  • IL-8
  • monocytes
  • neutrophils

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Matsumoto, T., Miike, T., Nelson, R. P., Trudeau, W. L., Lockey, R. F., & Yodoi, J. (1993). Elevated serum levels of IL-8 in patients with HIV infection. Clinical and Experimental Immunology, 93(2), 149-151.