Elevated serum levels of IL-8 in patients with HIV infection

T. Matsumoto, T. Miike, Robert Nelson, W. L. Trudeau, R. F. Lockey, J. Yodoi

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Serum levels of IL-8 were determined in HIV-infected individuals and the results were compared with those for HIV- controls. The IL-8 levels were measured by an ELISA with a MoAb and a polyclonal antibody to recombinant IL-8. The means and 95% confidence intervals of IL-8 in sera of 36 HIV-infected individuals and 32 matched controls were 275 and 216-349 pg/ml, and 8 and 4-14 pg/ml, respectively, showing a 34-fold increase in IL-8 in the circulation of HIV-infected individuals. This increase does not appear to be related to the disease state, infection or systemic medical agents. This finding suggests the possible involvement of IL-8 in the pathogenesis of HIV-induced disease.

Original languageEnglish (US)
Pages (from-to)149-151
Number of pages3
JournalClinical and Experimental Immunology
Volume93
Issue number2
StatePublished - 1993
Externally publishedYes

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Interleukin-8
HIV Infections
HIV
Serum
Enzyme-Linked Immunosorbent Assay
Confidence Intervals
Antibodies
Infection

Keywords

  • AIDS
  • HIV infection
  • IL-8
  • monocytes
  • neutrophils

ASJC Scopus subject areas

  • Immunology

Cite this

Matsumoto, T., Miike, T., Nelson, R., Trudeau, W. L., Lockey, R. F., & Yodoi, J. (1993). Elevated serum levels of IL-8 in patients with HIV infection. Clinical and Experimental Immunology, 93(2), 149-151.

Elevated serum levels of IL-8 in patients with HIV infection. / Matsumoto, T.; Miike, T.; Nelson, Robert; Trudeau, W. L.; Lockey, R. F.; Yodoi, J.

In: Clinical and Experimental Immunology, Vol. 93, No. 2, 1993, p. 149-151.

Research output: Contribution to journalArticle

Matsumoto, T, Miike, T, Nelson, R, Trudeau, WL, Lockey, RF & Yodoi, J 1993, 'Elevated serum levels of IL-8 in patients with HIV infection', Clinical and Experimental Immunology, vol. 93, no. 2, pp. 149-151.
Matsumoto T, Miike T, Nelson R, Trudeau WL, Lockey RF, Yodoi J. Elevated serum levels of IL-8 in patients with HIV infection. Clinical and Experimental Immunology. 1993;93(2):149-151.
Matsumoto, T. ; Miike, T. ; Nelson, Robert ; Trudeau, W. L. ; Lockey, R. F. ; Yodoi, J. / Elevated serum levels of IL-8 in patients with HIV infection. In: Clinical and Experimental Immunology. 1993 ; Vol. 93, No. 2. pp. 149-151.
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