Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii

Krista L. Stilger, William J. Sullivan

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background: Protein acetylation is prevalent in mitochondria, yet acetyltransferases mediating this activity are unknown. Results: Toxoplasma Elongator protein 3 (Elp3) possesses a unique C-terminal transmembrane domain necessary and sufficient to target it to the mitochondria. Conclusion: Elp3 is an essential tail-anchored mitochondrial acetyltransferase in Toxoplasma. Significance: Elp3 has conserved functions involving mitochondria that may predate its established role in transcription.

Original languageEnglish (US)
Pages (from-to)25318-25329
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
StatePublished - Aug 30 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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