Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii

Krista L. Stilger; William J. Sullivan

doi:10.1074/jbc.M113.491373

Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii

Krista L. Stilger, William J. Sullivan

Pharmacology & Toxicology

Research output: Contribution to journal › Article

17 Scopus citations

Abstract

Background: Protein acetylation is prevalent in mitochondria, yet acetyltransferases mediating this activity are unknown. Results: Toxoplasma Elongator protein 3 (Elp3) possesses a unique C-terminal transmembrane domain necessary and sufficient to target it to the mitochondria. Conclusion: Elp3 is an essential tail-anchored mitochondrial acetyltransferase in Toxoplasma. Significance: Elp3 has conserved functions involving mitochondria that may predate its established role in transcription.

Original language	English (US)
Pages (from-to)	25318-25329
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	35
DOIs	https://doi.org/10.1074/jbc.M113.491373
State	Published - Aug 30 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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Stilger, K. L., & Sullivan, W. J. (2013). Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii. Journal of Biological Chemistry, 288(35), 25318-25329. https://doi.org/10.1074/jbc.M113.491373

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