Abstract
Background: Protein acetylation is prevalent in mitochondria, yet acetyltransferases mediating this activity are unknown. Results: Toxoplasma Elongator protein 3 (Elp3) possesses a unique C-terminal transmembrane domain necessary and sufficient to target it to the mitochondria. Conclusion: Elp3 is an essential tail-anchored mitochondrial acetyltransferase in Toxoplasma. Significance: Elp3 has conserved functions involving mitochondria that may predate its established role in transcription.
| Original language | English |
|---|---|
| Pages (from-to) | 25318-25329 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 35 |
| DOIs | |
| State | Published - Aug 30 2013 |
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ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii. / Stilger, Krista L.; Sullivan, William.
In: Journal of Biological Chemistry, Vol. 288, No. 35, 30.08.2013, p. 25318-25329.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii
AU - Stilger, Krista L.
AU - Sullivan, William
PY - 2013/8/30
Y1 - 2013/8/30
N2 - Background: Protein acetylation is prevalent in mitochondria, yet acetyltransferases mediating this activity are unknown. Results: Toxoplasma Elongator protein 3 (Elp3) possesses a unique C-terminal transmembrane domain necessary and sufficient to target it to the mitochondria. Conclusion: Elp3 is an essential tail-anchored mitochondrial acetyltransferase in Toxoplasma. Significance: Elp3 has conserved functions involving mitochondria that may predate its established role in transcription.
AB - Background: Protein acetylation is prevalent in mitochondria, yet acetyltransferases mediating this activity are unknown. Results: Toxoplasma Elongator protein 3 (Elp3) possesses a unique C-terminal transmembrane domain necessary and sufficient to target it to the mitochondria. Conclusion: Elp3 is an essential tail-anchored mitochondrial acetyltransferase in Toxoplasma. Significance: Elp3 has conserved functions involving mitochondria that may predate its established role in transcription.
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UR - http://www.scopus.com/inward/citedby.url?scp=84883371503&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.491373
DO - 10.1074/jbc.M113.491373
M3 - Article
C2 - 23878194
AN - SCOPUS:84883371503
VL - 288
SP - 25318
EP - 25329
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 35
ER -