Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii

Krista L. Stilger, William Sullivan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Protein acetylation is prevalent in mitochondria, yet acetyltransferases mediating this activity are unknown. Results: Toxoplasma Elongator protein 3 (Elp3) possesses a unique C-terminal transmembrane domain necessary and sufficient to target it to the mitochondria. Conclusion: Elp3 is an essential tail-anchored mitochondrial acetyltransferase in Toxoplasma. Significance: Elp3 has conserved functions involving mitochondria that may predate its established role in transcription.

Original languageEnglish
Pages (from-to)25318-25329
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
StatePublished - Aug 30 2013

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Acetyltransferases
Mitochondrial Proteins
Toxoplasma
Lysine
Mitochondria
Proteins
Acetylation
Transcription
Prednisolone
Lysine Acetyltransferases

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in toxoplasma gondii. / Stilger, Krista L.; Sullivan, William.

In: Journal of Biological Chemistry, Vol. 288, No. 35, 30.08.2013, p. 25318-25329.

Research output: Contribution to journalArticle

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