Emerging insights into the function of kinesin-8 proteins in microtubule length regulation

Sanjay Shrestha, Mark Hazelbaker, Amber L. Yount, Claire E. Walczak

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.

Original languageEnglish (US)
Article number1
JournalBiomolecules
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • Microtubule dynamics
  • Mitosis
  • Molecular motor protein
  • Spindle

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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