Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation

Sanjay Shrestha, Mark Hazelbaker, Amber L. Yount, Claire Walczak

Research output: Contribution to journalReview article

Abstract

Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization.

Original languageEnglish (US)
JournalBiomolecules
Volume9
Issue number1
DOIs
StatePublished - Dec 20 2018

Fingerprint

Microtubule Proteins
Kinesin
Microtubules
Proteins
Chromosomes
Chromosome Segregation
Spindle Apparatus
Mitosis
Motor Activity

Keywords

  • microtubule dynamics
  • mitosis
  • molecular motor protein
  • spindle

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation. / Shrestha, Sanjay; Hazelbaker, Mark; Yount, Amber L.; Walczak, Claire.

In: Biomolecules, Vol. 9, No. 1, 20.12.2018.

Research output: Contribution to journalReview article

Shrestha, Sanjay ; Hazelbaker, Mark ; Yount, Amber L. ; Walczak, Claire. / Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation. In: Biomolecules. 2018 ; Vol. 9, No. 1.
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