Emerging Molecular Therapies for Brain Tumors

Erwin G. Van Meir, Anita Bellail, Surasak Phuphanich

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This article briefly reviews the basic research findings on brain tumors made in the last decade and how they are now impacting clinical trials. Major Improvements in our understanding of the genetic, molecular, and biological mechanisms that lead to brain tumor development have been made. These include mechanistic insights on how tumor cells overcome cell cycle control, evade programmed cell death, induce blood vessel formation, and escape immune regulation. These advances have been tremendously accelerated by the availability of novel whole-genome analysis technologies. These findings are now being translated into innovative clinical trials that provide new hope for patients with these devastating diseases.

Original languageEnglish (US)
Pages (from-to)38-46
Number of pages9
JournalSeminars in Oncology
Volume31
Issue number2 SUPPL. 4
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

Fingerprint

Brain Neoplasms
Clinical Trials
Cell Cycle Checkpoints
Blood Vessels
Molecular Biology
Cell Death
Genome
Technology
Therapeutics
Research
Neoplasms

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

Emerging Molecular Therapies for Brain Tumors. / Van Meir, Erwin G.; Bellail, Anita; Phuphanich, Surasak.

In: Seminars in Oncology, Vol. 31, No. 2 SUPPL. 4, 01.01.2004, p. 38-46.

Research output: Contribution to journalArticle

Van Meir, Erwin G. ; Bellail, Anita ; Phuphanich, Surasak. / Emerging Molecular Therapies for Brain Tumors. In: Seminars in Oncology. 2004 ; Vol. 31, No. 2 SUPPL. 4. pp. 38-46.
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