Emerging Molecular Therapies for Brain Tumors

Erwin G. Van Meir, Anita Bellail, Surasak Phuphanich

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

This article briefly reviews the basic research findings on brain tumors made in the last decade and how they are now impacting clinical trials. Major Improvements in our understanding of the genetic, molecular, and biological mechanisms that lead to brain tumor development have been made. These include mechanistic insights on how tumor cells overcome cell cycle control, evade programmed cell death, induce blood vessel formation, and escape immune regulation. These advances have been tremendously accelerated by the availability of novel whole-genome analysis technologies. These findings are now being translated into innovative clinical trials that provide new hope for patients with these devastating diseases.

Original languageEnglish (US)
Pages (from-to)38-46
Number of pages9
JournalSeminars in Oncology
Volume31
Issue number2 SUPPL. 4
DOIs
StatePublished - Apr 2004

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ASJC Scopus subject areas

  • Hematology
  • Oncology

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