Emerging therapeutic delivery capabilities and challenges utilizing enzyme/protein packaged bacterial vesicles

Nathan J. Alves, Kendrick B. Turner, Igor L. Medintz, Scott A. Walper

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Nanoparticle-based therapeutics are poised to play a critical role in treating disease. These complex multifunctional drug delivery vehicles provide for the passive and active targeted delivery of numerous small molecule, peptide and protein-derived pharmaceuticals. This article will first discuss some of the current state of the art nanoparticle classes (dendrimers, lipid-based, polymeric and inorganic), highlighting benefits/drawbacks associated with their implementation. We will then discuss an emerging class of nanoparticle therapeutics, bacterial outer membrane vesicles, that can provide many of the nanoparticle benefits while simplifying assembly. Through molecular biology techniques; outer membrane vesicle hijacking potentially allows for stringent control over nanoparticle production allowing for targeted protein packaged nanoparticles to be fully synthesized by bacteria.

Original languageEnglish (US)
Pages (from-to)873-887
Number of pages15
JournalTherapeutic Delivery
Volume6
Issue number7
DOIs
StatePublished - Jul 1 2015

ASJC Scopus subject areas

  • Pharmaceutical Science

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