Emerging therapeutic delivery capabilities and challenges utilizing enzyme/protein packaged bacterial vesicles

Nathan Alves, Kendrick B. Turner, Igor L. Medintz, Scott A. Walper

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Nanoparticle-based therapeutics are poised to play a critical role in treating disease. These complex multifunctional drug delivery vehicles provide for the passive and active targeted delivery of numerous small molecule, peptide and protein-derived pharmaceuticals. This article will first discuss some of the current state of the art nanoparticle classes (dendrimers, lipid-based, polymeric and inorganic), highlighting benefits/drawbacks associated with their implementation. We will then discuss an emerging class of nanoparticle therapeutics, bacterial outer membrane vesicles, that can provide many of the nanoparticle benefits while simplifying assembly. Through molecular biology techniques; outer membrane vesicle hijacking potentially allows for stringent control over nanoparticle production allowing for targeted protein packaged nanoparticles to be fully synthesized by bacteria.

Original languageEnglish (US)
Pages (from-to)873-887
Number of pages15
JournalTherapeutic Delivery
Volume6
Issue number7
DOIs
StatePublished - Jul 1 2015
Externally publishedYes

Fingerprint

Bacterial Proteins
Nanoparticles
Enzymes
Therapeutics
Dendrimers
Membranes
Pharmaceutical Preparations
Molecular Biology
Proteins
Bacteria
Lipids
Peptides

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Emerging therapeutic delivery capabilities and challenges utilizing enzyme/protein packaged bacterial vesicles. / Alves, Nathan; Turner, Kendrick B.; Medintz, Igor L.; Walper, Scott A.

In: Therapeutic Delivery, Vol. 6, No. 7, 01.07.2015, p. 873-887.

Research output: Contribution to journalReview article

Alves, Nathan ; Turner, Kendrick B. ; Medintz, Igor L. ; Walper, Scott A. / Emerging therapeutic delivery capabilities and challenges utilizing enzyme/protein packaged bacterial vesicles. In: Therapeutic Delivery. 2015 ; Vol. 6, No. 7. pp. 873-887.
@article{d8626b6dd6ad4dfda110410df40825d9,
title = "Emerging therapeutic delivery capabilities and challenges utilizing enzyme/protein packaged bacterial vesicles",
abstract = "Nanoparticle-based therapeutics are poised to play a critical role in treating disease. These complex multifunctional drug delivery vehicles provide for the passive and active targeted delivery of numerous small molecule, peptide and protein-derived pharmaceuticals. This article will first discuss some of the current state of the art nanoparticle classes (dendrimers, lipid-based, polymeric and inorganic), highlighting benefits/drawbacks associated with their implementation. We will then discuss an emerging class of nanoparticle therapeutics, bacterial outer membrane vesicles, that can provide many of the nanoparticle benefits while simplifying assembly. Through molecular biology techniques; outer membrane vesicle hijacking potentially allows for stringent control over nanoparticle production allowing for targeted protein packaged nanoparticles to be fully synthesized by bacteria.",
author = "Nathan Alves and Turner, {Kendrick B.} and Medintz, {Igor L.} and Walper, {Scott A.}",
year = "2015",
month = "7",
day = "1",
doi = "10.4155/tde.15.40",
language = "English (US)",
volume = "6",
pages = "873--887",
journal = "Therapeutic Delivery",
issn = "2041-5990",
publisher = "Future Science",
number = "7",

}

TY - JOUR

T1 - Emerging therapeutic delivery capabilities and challenges utilizing enzyme/protein packaged bacterial vesicles

AU - Alves, Nathan

AU - Turner, Kendrick B.

AU - Medintz, Igor L.

AU - Walper, Scott A.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Nanoparticle-based therapeutics are poised to play a critical role in treating disease. These complex multifunctional drug delivery vehicles provide for the passive and active targeted delivery of numerous small molecule, peptide and protein-derived pharmaceuticals. This article will first discuss some of the current state of the art nanoparticle classes (dendrimers, lipid-based, polymeric and inorganic), highlighting benefits/drawbacks associated with their implementation. We will then discuss an emerging class of nanoparticle therapeutics, bacterial outer membrane vesicles, that can provide many of the nanoparticle benefits while simplifying assembly. Through molecular biology techniques; outer membrane vesicle hijacking potentially allows for stringent control over nanoparticle production allowing for targeted protein packaged nanoparticles to be fully synthesized by bacteria.

AB - Nanoparticle-based therapeutics are poised to play a critical role in treating disease. These complex multifunctional drug delivery vehicles provide for the passive and active targeted delivery of numerous small molecule, peptide and protein-derived pharmaceuticals. This article will first discuss some of the current state of the art nanoparticle classes (dendrimers, lipid-based, polymeric and inorganic), highlighting benefits/drawbacks associated with their implementation. We will then discuss an emerging class of nanoparticle therapeutics, bacterial outer membrane vesicles, that can provide many of the nanoparticle benefits while simplifying assembly. Through molecular biology techniques; outer membrane vesicle hijacking potentially allows for stringent control over nanoparticle production allowing for targeted protein packaged nanoparticles to be fully synthesized by bacteria.

UR - http://www.scopus.com/inward/record.url?scp=84938352705&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938352705&partnerID=8YFLogxK

U2 - 10.4155/tde.15.40

DO - 10.4155/tde.15.40

M3 - Review article

VL - 6

SP - 873

EP - 887

JO - Therapeutic Delivery

JF - Therapeutic Delivery

SN - 2041-5990

IS - 7

ER -