Emerging tick-borne infections in mainland China

An increasing public health threat

Li Qun Fang, Kun Liu, Xin Lou Li, Song Liang, Yang Yang, Hong Wu Yao, Ruo Xi Sun, Ye Sun, Wan Jun Chen, Shu Qing Zuo, Mai Juan Ma, Hao Li, Jia Fu Jiang, Wei Liu, X. Yang, Gregory C. Gray, Peter J. Krause, Wu Chun Cao

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Since the beginning of the 1980s, 33 emerging tick-borne agents have been identified in mainland China, including eight species of spotted fever group rickettsiae, seven species in the family Anaplasmataceae, six genospecies in the complex Borrelia burgdorferi sensu lato, 11 species of Babesia, and the virus causing severe fever with thrombocytopenia syndrome. In this Review we have mapped the geographical distributions of human cases of infection. 15 of the 33 emerging tick-borne agents have been reported to cause human disease, and their clinical characteristics have been described. The non-specific clinical manifestations caused by tick-borne pathogens present a major diagnostic challenge and most physicians are unfamiliar with the many tick-borne diseases that present with non-specific symptoms in the early stages of the illness. Advances in and application of modern molecular techniques should help with identification of emerging tick-borne pathogens and improve laboratory diagnosis of human infections. We expect that more novel tick-borne infections in ticks and animals will be identified and additional emerging tick-borne diseases in human beings will be discovered.

Original languageEnglish (US)
Pages (from-to)1467-1479
Number of pages13
JournalThe Lancet Infectious Diseases
Volume15
Issue number12
DOIs
StatePublished - Dec 1 2015

Fingerprint

Tick-Borne Diseases
Ticks
China
Public Health
Anaplasmataceae
Fever
Borrelia burgdorferi Group
Babesia
Rickettsia
Clinical Laboratory Techniques
Infection
Thrombocytopenia
Viruses
Physicians

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

Fang, L. Q., Liu, K., Li, X. L., Liang, S., Yang, Y., Yao, H. W., ... Cao, W. C. (2015). Emerging tick-borne infections in mainland China: An increasing public health threat. The Lancet Infectious Diseases, 15(12), 1467-1479. https://doi.org/10.1016/S1473-3099(15)00177-2

Emerging tick-borne infections in mainland China : An increasing public health threat. / Fang, Li Qun; Liu, Kun; Li, Xin Lou; Liang, Song; Yang, Yang; Yao, Hong Wu; Sun, Ruo Xi; Sun, Ye; Chen, Wan Jun; Zuo, Shu Qing; Ma, Mai Juan; Li, Hao; Jiang, Jia Fu; Liu, Wei; Yang, X.; Gray, Gregory C.; Krause, Peter J.; Cao, Wu Chun.

In: The Lancet Infectious Diseases, Vol. 15, No. 12, 01.12.2015, p. 1467-1479.

Research output: Contribution to journalArticle

Fang, LQ, Liu, K, Li, XL, Liang, S, Yang, Y, Yao, HW, Sun, RX, Sun, Y, Chen, WJ, Zuo, SQ, Ma, MJ, Li, H, Jiang, JF, Liu, W, Yang, X, Gray, GC, Krause, PJ & Cao, WC 2015, 'Emerging tick-borne infections in mainland China: An increasing public health threat', The Lancet Infectious Diseases, vol. 15, no. 12, pp. 1467-1479. https://doi.org/10.1016/S1473-3099(15)00177-2
Fang, Li Qun ; Liu, Kun ; Li, Xin Lou ; Liang, Song ; Yang, Yang ; Yao, Hong Wu ; Sun, Ruo Xi ; Sun, Ye ; Chen, Wan Jun ; Zuo, Shu Qing ; Ma, Mai Juan ; Li, Hao ; Jiang, Jia Fu ; Liu, Wei ; Yang, X. ; Gray, Gregory C. ; Krause, Peter J. ; Cao, Wu Chun. / Emerging tick-borne infections in mainland China : An increasing public health threat. In: The Lancet Infectious Diseases. 2015 ; Vol. 15, No. 12. pp. 1467-1479.
@article{1d72cb78754043489f5d10d195597ce4,
title = "Emerging tick-borne infections in mainland China: An increasing public health threat",
abstract = "Since the beginning of the 1980s, 33 emerging tick-borne agents have been identified in mainland China, including eight species of spotted fever group rickettsiae, seven species in the family Anaplasmataceae, six genospecies in the complex Borrelia burgdorferi sensu lato, 11 species of Babesia, and the virus causing severe fever with thrombocytopenia syndrome. In this Review we have mapped the geographical distributions of human cases of infection. 15 of the 33 emerging tick-borne agents have been reported to cause human disease, and their clinical characteristics have been described. The non-specific clinical manifestations caused by tick-borne pathogens present a major diagnostic challenge and most physicians are unfamiliar with the many tick-borne diseases that present with non-specific symptoms in the early stages of the illness. Advances in and application of modern molecular techniques should help with identification of emerging tick-borne pathogens and improve laboratory diagnosis of human infections. We expect that more novel tick-borne infections in ticks and animals will be identified and additional emerging tick-borne diseases in human beings will be discovered.",
author = "Fang, {Li Qun} and Kun Liu and Li, {Xin Lou} and Song Liang and Yang Yang and Yao, {Hong Wu} and Sun, {Ruo Xi} and Ye Sun and Chen, {Wan Jun} and Zuo, {Shu Qing} and Ma, {Mai Juan} and Hao Li and Jiang, {Jia Fu} and Wei Liu and X. Yang and Gray, {Gregory C.} and Krause, {Peter J.} and Cao, {Wu Chun}",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/S1473-3099(15)00177-2",
language = "English (US)",
volume = "15",
pages = "1467--1479",
journal = "The Lancet Infectious Diseases",
issn = "1473-3099",
publisher = "Lancet Publishing Group",
number = "12",

}

TY - JOUR

T1 - Emerging tick-borne infections in mainland China

T2 - An increasing public health threat

AU - Fang, Li Qun

AU - Liu, Kun

AU - Li, Xin Lou

AU - Liang, Song

AU - Yang, Yang

AU - Yao, Hong Wu

AU - Sun, Ruo Xi

AU - Sun, Ye

AU - Chen, Wan Jun

AU - Zuo, Shu Qing

AU - Ma, Mai Juan

AU - Li, Hao

AU - Jiang, Jia Fu

AU - Liu, Wei

AU - Yang, X.

AU - Gray, Gregory C.

AU - Krause, Peter J.

AU - Cao, Wu Chun

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Since the beginning of the 1980s, 33 emerging tick-borne agents have been identified in mainland China, including eight species of spotted fever group rickettsiae, seven species in the family Anaplasmataceae, six genospecies in the complex Borrelia burgdorferi sensu lato, 11 species of Babesia, and the virus causing severe fever with thrombocytopenia syndrome. In this Review we have mapped the geographical distributions of human cases of infection. 15 of the 33 emerging tick-borne agents have been reported to cause human disease, and their clinical characteristics have been described. The non-specific clinical manifestations caused by tick-borne pathogens present a major diagnostic challenge and most physicians are unfamiliar with the many tick-borne diseases that present with non-specific symptoms in the early stages of the illness. Advances in and application of modern molecular techniques should help with identification of emerging tick-borne pathogens and improve laboratory diagnosis of human infections. We expect that more novel tick-borne infections in ticks and animals will be identified and additional emerging tick-borne diseases in human beings will be discovered.

AB - Since the beginning of the 1980s, 33 emerging tick-borne agents have been identified in mainland China, including eight species of spotted fever group rickettsiae, seven species in the family Anaplasmataceae, six genospecies in the complex Borrelia burgdorferi sensu lato, 11 species of Babesia, and the virus causing severe fever with thrombocytopenia syndrome. In this Review we have mapped the geographical distributions of human cases of infection. 15 of the 33 emerging tick-borne agents have been reported to cause human disease, and their clinical characteristics have been described. The non-specific clinical manifestations caused by tick-borne pathogens present a major diagnostic challenge and most physicians are unfamiliar with the many tick-borne diseases that present with non-specific symptoms in the early stages of the illness. Advances in and application of modern molecular techniques should help with identification of emerging tick-borne pathogens and improve laboratory diagnosis of human infections. We expect that more novel tick-borne infections in ticks and animals will be identified and additional emerging tick-borne diseases in human beings will be discovered.

UR - http://www.scopus.com/inward/record.url?scp=84960456651&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960456651&partnerID=8YFLogxK

U2 - 10.1016/S1473-3099(15)00177-2

DO - 10.1016/S1473-3099(15)00177-2

M3 - Article

VL - 15

SP - 1467

EP - 1479

JO - The Lancet Infectious Diseases

JF - The Lancet Infectious Diseases

SN - 1473-3099

IS - 12

ER -