Encephalitis complicating smallpox vaccination

Augusto Miravalle, Karen Roos

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A smallpox vaccination program has been initiated. The vaccine is a live virus that was used in the last century. Postvaccinal encephalitis is a complication of this vaccine. The clinical presentation, course, neuroimaging findings, and spinal fluid abnormalities are similar to a disorder that physicians are familiar with, acute disseminated encephalomyelitis. This complication can be prevented with the administration of antivaccinia gamma globulin at the time of vaccination. Antivaccinia gamma globulin is not efficacious once this complication occurs. Intravenous methylprednisolone is the recommended therapy, although intravenous immunoglobulin and plasmapheresis should be investigated in the treatment of postvaccinal encephalitis.

Original languageEnglish
Pages (from-to)925-928
Number of pages4
JournalArchives of Neurology
Volume60
Issue number7
DOIs
StatePublished - Jul 1 2003

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Acute Disseminated Encephalomyelitis
Smallpox
Encephalitis
Vaccination
gamma-Globulins
Vaccines
Plasmapheresis
Intravenous Immunoglobulins
Methylprednisolone
Neuroimaging
Viruses
Physicians
Therapeutics
Complications
Vaccine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Encephalitis complicating smallpox vaccination. / Miravalle, Augusto; Roos, Karen.

In: Archives of Neurology, Vol. 60, No. 7, 01.07.2003, p. 925-928.

Research output: Contribution to journalArticle

Miravalle, Augusto ; Roos, Karen. / Encephalitis complicating smallpox vaccination. In: Archives of Neurology. 2003 ; Vol. 60, No. 7. pp. 925-928.
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