Endochondral Ossification for Enhancing Bone Regeneration: Converging Native Extracellular Matrix Biomaterials and Developmental Engineering in Vivo

S. Connor Dennis, Cory J. Berkland, Lynda F. Bonewald, Michael S. Detamore

Research output: Contribution to journalReview article

28 Scopus citations


Autologous bone grafting (ABG) d standard of treatment in bone regenerative surgery. Consequently, many marginally successful bone tissue engineering strategies have focused on mimicking portions of ABG's "ideal" osteoconductive, osteoinductive, and osteogenic composition resembling the late reparative stage extracellular matrix (ECM) in bone fracture repair, also known as the "hard" or "bony" callus. An alternative, less common approach that has emerged in the last decade harnesses endochondral (EC) ossification through developmental engineering principles, which acknowledges that the molecular and cellular mechanisms involved in developmental skeletogenesis, specifically EC ossification, are closely paralleled during native bone healing.

Original languageEnglish (US)
Pages (from-to)247-266
Number of pages20
JournalTissue Engineering - Part B: Reviews
Issue number3
StatePublished - Jun 1 2015
Externally publishedYes


ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

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