Endochondral Ossification for Enhancing Bone Regeneration

Converging Native Extracellular Matrix Biomaterials and Developmental Engineering in Vivo

S. Connor Dennis, Cory J. Berkland, Lynda Bonewald, Michael S. Detamore

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Autologous bone grafting (ABG) d standard of treatment in bone regenerative surgery. Consequently, many marginally successful bone tissue engineering strategies have focused on mimicking portions of ABG's "ideal" osteoconductive, osteoinductive, and osteogenic composition resembling the late reparative stage extracellular matrix (ECM) in bone fracture repair, also known as the "hard" or "bony" callus. An alternative, less common approach that has emerged in the last decade harnesses endochondral (EC) ossification through developmental engineering principles, which acknowledges that the molecular and cellular mechanisms involved in developmental skeletogenesis, specifically EC ossification, are closely paralleled during native bone healing.

Original languageEnglish (US)
Pages (from-to)247-266
Number of pages20
JournalTissue Engineering - Part B: Reviews
Volume21
Issue number3
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

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Bone Regeneration
Biocompatible Materials
Osteogenesis
Biomaterials
Extracellular Matrix
Bone
Bone and Bones
Bone Transplantation
Bone Fractures
Bony Callus
Tissue Engineering
Tissue engineering
Surgery
Repair
Chemical analysis
Therapeutics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Bioengineering
  • Biochemistry

Cite this

Endochondral Ossification for Enhancing Bone Regeneration : Converging Native Extracellular Matrix Biomaterials and Developmental Engineering in Vivo. / Dennis, S. Connor; Berkland, Cory J.; Bonewald, Lynda; Detamore, Michael S.

In: Tissue Engineering - Part B: Reviews, Vol. 21, No. 3, 01.06.2015, p. 247-266.

Research output: Contribution to journalReview article

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