Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits: A systematic review and meta-analysis

Yan Song, Elizabeth L. Chou, Aileen Baecker, Nai Chieh Y. You, Yiqing Song, Qi Sun, Simin Liu

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Background: Elevated blood or urinary concentrations of endocrine-disrupting chemicals (EDCs) may be related to increased risk of type 2 diabetes (T2D). The aim of the present study was to assess the role of EDCs in affecting risk of T2D and related metabolic traits. Methods: MEDLINE was searched for cross-sectional and prospective studies published before 8 March 2014 into the association between EDCs (dioxin, polychlorinated biphenyl [PCB], chlorinated pesticide, bisphenol A [BPA], phthalate) and T2D and related metabolic traits. Three investigators independently extracted information on study design, participant characteristics, EDC types and concentrations, and association measures. Results: Forty-one cross-sectional and eight prospective studies from ethnically diverse populations were included in the analysis. Serum concentrations of dioxins, PCBs, and chlorinated pesticides were significantly associated with T2D risk; comparing the highest to lowest concentration category, the pooled relative risks (RR) were 1.91 (95% confidence interval [CI] 1.44–2.54) for dioxins, 2.39 (95% CI 1.86–3.08) for total PCBs, and 2.30 (95% CI 1.81–2.93) for chlorinated pesticides. Urinary concentrations of BPA and phthalates were also associated with T2D risk; comparing the highest to lowest concentration categories, the pooled RR were 1.45 (95% CI 1.13–1.87) for BPA and 1.48 (95% CI 0.98–2.25) for phthalates. Further, EDC concentrations were associated with indicators of impaired fasting glucose and insulin resistance. Conclusions: Persistent and non-persistent EDCs may affect the risk of T2D. There is an urgent need for further investigation of EDCs, especially non-persistent ones, and T2D risk in large prospective studies.

Original languageEnglish (US)
Pages (from-to)516-532
Number of pages17
JournalJournal of Diabetes
Volume8
Issue number4
DOIs
StatePublished - Jul 1 2016

Fingerprint

Endocrine Disruptors
Type 2 Diabetes Mellitus
Meta-Analysis
Dioxins
Confidence Intervals
Pesticides
Polychlorinated Biphenyls
Prospective Studies
MEDLINE
Insulin Resistance
Fasting
Cross-Sectional Studies
Research Personnel
Glucose

Keywords

  • bisphenol A
  • diabetes
  • endocrine-disrupting chemical
  • meta-analysis
  • phthalate

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits : A systematic review and meta-analysis. / Song, Yan; Chou, Elizabeth L.; Baecker, Aileen; You, Nai Chieh Y.; Song, Yiqing; Sun, Qi; Liu, Simin.

In: Journal of Diabetes, Vol. 8, No. 4, 01.07.2016, p. 516-532.

Research output: Contribution to journalArticle

Song, Yan ; Chou, Elizabeth L. ; Baecker, Aileen ; You, Nai Chieh Y. ; Song, Yiqing ; Sun, Qi ; Liu, Simin. / Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits : A systematic review and meta-analysis. In: Journal of Diabetes. 2016 ; Vol. 8, No. 4. pp. 516-532.
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abstract = "Background: Elevated blood or urinary concentrations of endocrine-disrupting chemicals (EDCs) may be related to increased risk of type 2 diabetes (T2D). The aim of the present study was to assess the role of EDCs in affecting risk of T2D and related metabolic traits. Methods: MEDLINE was searched for cross-sectional and prospective studies published before 8 March 2014 into the association between EDCs (dioxin, polychlorinated biphenyl [PCB], chlorinated pesticide, bisphenol A [BPA], phthalate) and T2D and related metabolic traits. Three investigators independently extracted information on study design, participant characteristics, EDC types and concentrations, and association measures. Results: Forty-one cross-sectional and eight prospective studies from ethnically diverse populations were included in the analysis. Serum concentrations of dioxins, PCBs, and chlorinated pesticides were significantly associated with T2D risk; comparing the highest to lowest concentration category, the pooled relative risks (RR) were 1.91 (95{\%} confidence interval [CI] 1.44–2.54) for dioxins, 2.39 (95{\%} CI 1.86–3.08) for total PCBs, and 2.30 (95{\%} CI 1.81–2.93) for chlorinated pesticides. Urinary concentrations of BPA and phthalates were also associated with T2D risk; comparing the highest to lowest concentration categories, the pooled RR were 1.45 (95{\%} CI 1.13–1.87) for BPA and 1.48 (95{\%} CI 0.98–2.25) for phthalates. Further, EDC concentrations were associated with indicators of impaired fasting glucose and insulin resistance. Conclusions: Persistent and non-persistent EDCs may affect the risk of T2D. There is an urgent need for further investigation of EDCs, especially non-persistent ones, and T2D risk in large prospective studies.",
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AU - Chou, Elizabeth L.

AU - Baecker, Aileen

AU - You, Nai Chieh Y.

AU - Song, Yiqing

AU - Sun, Qi

AU - Liu, Simin

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