Endocytic disturbances distinguish among subtypes of Alzheimer's disease and related disorders

Anne Cataldo, G. William Rebeck, Bernadino Ghetti, Christine Hulette, Carol Lippa, Christine Van Broeckhoven, Cornelia Van Duijn, Patrick Cras, Nenad Bogdanovic, Thomas Bird, Corrinne Peterhoff, Ralph Nixon

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


The endocytic pathway is important in amyloid precursor protein (APP) processing and β-amyloid formation. Our studies have shown that endocytic pathway activation is a prominent and early feature of neurons in vulnerable regions of the brain in sporadic Alzheimer's disease. We report that endocytic pathway abnormalities are present not only in neurons, but in cerebral endothelia in Alzheimer's disease caused by certain APP mutations. The presence or absence of endocytic abnormalities distinguish subtypes of familial Alzheimer's disease linked to APP mutations from presenilin mutations, supporting the notion that different cellular pathways are involved in the altered processing of APP leading to increased β-amyloid generation in certain of these different Alzheimer's disease subtypes.

Original languageEnglish (US)
Pages (from-to)661-665
Number of pages5
JournalAnnals of Neurology
Issue number5
StatePublished - Nov 12 2001

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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