Endodermal sinus tumor of the mediastinum

M. E. Kuzur, M. A. Cobleigh, F. A. Greco, Lawrence Einhorn, R. K. Oldham

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Endodermal sinus tumor (EST) of the mediastinum is a rare germ-cell neoplasm affecting mainly young adult males. Ten patients with EST were treated with a multimodality approach that included surgery, chemotherapy, and radiotherapy. All patients had relapses after achieving a transient response except one who is still in complete remission more than five years following the diagnosis of the disease. Optimal therapy for this neoplasm has yet to be discovered. The disease is a subset of extragonadal germ cell tumors which appears to be lethal in most cases, particularly when the primary tumor is unresectable. The first case of five-year disease-free survival is described

Original languageEnglish (US)
Pages (from-to)766-774
Number of pages9
JournalCancer
Volume50
Issue number4
DOIs
StatePublished - 1982

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Endodermal Sinus Tumor
Germ Cell and Embryonal Neoplasms
Mediastinum
Disease-Free Survival
Young Adult
Neoplasms
Radiotherapy
Recurrence
Drug Therapy
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Endodermal sinus tumor of the mediastinum. / Kuzur, M. E.; Cobleigh, M. A.; Greco, F. A.; Einhorn, Lawrence; Oldham, R. K.

In: Cancer, Vol. 50, No. 4, 1982, p. 766-774.

Research output: Contribution to journalArticle

Kuzur, M. E. ; Cobleigh, M. A. ; Greco, F. A. ; Einhorn, Lawrence ; Oldham, R. K. / Endodermal sinus tumor of the mediastinum. In: Cancer. 1982 ; Vol. 50, No. 4. pp. 766-774.
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