Endogenous erythroid colony-forming cells in fetal and newborn sheep

G. David Roodman, E. D. Zanjani

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In plasma clot cultures fetal, newborn, and adult sheep bone marrow cells respond to Ep, giving rise to large numbers of colonies of erythroid cells. In fetal and newborn, but not adult, sheep the marrow produced EEC in the absence of added Ep. The EEC-forming cells represent a transitory population of erythroid progenitors, persisting for approximately 2 month post-partum. The activity of these cells in the normal newborn sheep displayed a cyclic pattern, which was abolished in the presence of high circulating Ep levels. In both fetal and newborn sheep, EEC formation was inhibited by prior neutralization of Ep present in culture media with anti-Ep, suggesting that as in patients with PV the proliferation and/or differentiation of ECC-forming cells of sheep is subject to Ep control.

Original languageEnglish (US)
Pages (from-to)699-707
Number of pages9
JournalJournal of Laboratory and Clinical Medicine
Volume94
Issue number5
StatePublished - 1979
Externally publishedYes

Fingerprint

Sheep
Cells
European Union
Culture Media
Newborn Infant
Bone
Erythroid Cells
Plasmas
Bone Marrow Cells
Bone Marrow
Population

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Endogenous erythroid colony-forming cells in fetal and newborn sheep. / Roodman, G. David; Zanjani, E. D.

In: Journal of Laboratory and Clinical Medicine, Vol. 94, No. 5, 1979, p. 699-707.

Research output: Contribution to journalArticle

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