Endogenous opioid regulation of hypothalamo-pituitary-adrenal axis activity in schizophrenia

Owen M. Wolkowitz, Allen R. Doran, Alan Breier, Martin R. Cohen, David Pickar

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We utilized a naloxone challenge strategy to investigate the functioning of the endogenous opioid system (EOS) in schizophrenia. Patients with schizophrenia, who were on neuroleptic medication or drug-free, demonstrated a significantly larger serum cortisol response to opioid blockade by naloxone than did age- and sex-matched normal controls. Patients, but not normal controls, also demonstrated an inverse relationship between baseline cortisol and the magnitude of the response. This enhanced cortisol response is consistent with tonic hyperactivity of the EOS in schizophrenia.

Original languageEnglish (US)
Pages (from-to)366-373
Number of pages8
JournalBiological Psychiatry
Volume21
Issue number4
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Opioid Analgesics
Hydrocortisone
Schizophrenia
Naloxone
Antipsychotic Agents
Serum
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Endogenous opioid regulation of hypothalamo-pituitary-adrenal axis activity in schizophrenia. / Wolkowitz, Owen M.; Doran, Allen R.; Breier, Alan; Cohen, Martin R.; Pickar, David.

In: Biological Psychiatry, Vol. 21, No. 4, 1986, p. 366-373.

Research output: Contribution to journalArticle

Wolkowitz, Owen M. ; Doran, Allen R. ; Breier, Alan ; Cohen, Martin R. ; Pickar, David. / Endogenous opioid regulation of hypothalamo-pituitary-adrenal axis activity in schizophrenia. In: Biological Psychiatry. 1986 ; Vol. 21, No. 4. pp. 366-373.
@article{bcc96e0e9fff468785389476e50ea125,
title = "Endogenous opioid regulation of hypothalamo-pituitary-adrenal axis activity in schizophrenia",
abstract = "We utilized a naloxone challenge strategy to investigate the functioning of the endogenous opioid system (EOS) in schizophrenia. Patients with schizophrenia, who were on neuroleptic medication or drug-free, demonstrated a significantly larger serum cortisol response to opioid blockade by naloxone than did age- and sex-matched normal controls. Patients, but not normal controls, also demonstrated an inverse relationship between baseline cortisol and the magnitude of the response. This enhanced cortisol response is consistent with tonic hyperactivity of the EOS in schizophrenia.",
author = "Wolkowitz, {Owen M.} and Doran, {Allen R.} and Alan Breier and Cohen, {Martin R.} and David Pickar",
year = "1986",
doi = "10.1016/0006-3223(86)90164-2",
language = "English (US)",
volume = "21",
pages = "366--373",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "4",

}

TY - JOUR

T1 - Endogenous opioid regulation of hypothalamo-pituitary-adrenal axis activity in schizophrenia

AU - Wolkowitz, Owen M.

AU - Doran, Allen R.

AU - Breier, Alan

AU - Cohen, Martin R.

AU - Pickar, David

PY - 1986

Y1 - 1986

N2 - We utilized a naloxone challenge strategy to investigate the functioning of the endogenous opioid system (EOS) in schizophrenia. Patients with schizophrenia, who were on neuroleptic medication or drug-free, demonstrated a significantly larger serum cortisol response to opioid blockade by naloxone than did age- and sex-matched normal controls. Patients, but not normal controls, also demonstrated an inverse relationship between baseline cortisol and the magnitude of the response. This enhanced cortisol response is consistent with tonic hyperactivity of the EOS in schizophrenia.

AB - We utilized a naloxone challenge strategy to investigate the functioning of the endogenous opioid system (EOS) in schizophrenia. Patients with schizophrenia, who were on neuroleptic medication or drug-free, demonstrated a significantly larger serum cortisol response to opioid blockade by naloxone than did age- and sex-matched normal controls. Patients, but not normal controls, also demonstrated an inverse relationship between baseline cortisol and the magnitude of the response. This enhanced cortisol response is consistent with tonic hyperactivity of the EOS in schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=0022447150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022447150&partnerID=8YFLogxK

U2 - 10.1016/0006-3223(86)90164-2

DO - 10.1016/0006-3223(86)90164-2

M3 - Article

VL - 21

SP - 366

EP - 373

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 4

ER -