Endometrial brush biopsy for the diagnosis of endometrial cancer

Giuseppe Del Priore, Renee Williams, Carrie B. Harbatkin, Livia S. Wan, Khush Mittal, Grace C.H. Yang

Research output: Contribution to journalArticle

40 Scopus citations


OBJECTIVE: To evaluate a new technique for processing endometrial cytology for the diagnosis and exclusion of endometrial cancer. STUDY DESIGN: All women at risk for endometrial cancer with clinical indications for endometrial biopsy were evaluated by endometrial brush biopsy (Tao Brush, Cook OB-GYN, Bloomington, Indiana) and Pipelle (Cooper Surgical, Shelton, Connecticut) endometrial biopsies during one office visit. Patients were followed longitudinally for the development of endometrial cancer or until undergoing dilatation and curettage or hysterectomy. All comparisons were analyzed using the X 2 or t test. RESULTS: One hundred one women (mean age, 58; range, 35-86) had endometrial biopsies performed. Median follow-up was > 21 months (range, 3-29). Twenty-two had cancer or atypia, while the remaining had benign diagnoses. When correlated with the final diagnosis, the Tao Brush had 95.5% sensitivity and the Pipelle, 86% sensitivity. Both devices had 100% specificity, positive predictive value of 100% and negative predictive value of 98%. When the results of the two biopsy devices are considered together, the positive and negative predictive value for detecting or excluding endometrial cancer was 100%. Based on 1998 Medicare reimbursements, a simultaneous second office biopsy using the Tao brush could save approximately $67 per case as compared to a sonohistogram and much more when compared to dilatation and curettage. CONCLUSION: Endometrial cancer can be reliably detected and excluded using these two distinct office biopsy devices simultaneously during one office visit. In patients with an indication for endometrial biopsy, no further diagnostic test may be necessary to exclude or diagnose endometrial cancer or atypia.

Original languageEnglish (US)
Pages (from-to)439-443
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number5
StatePublished - May 1 2001


  • Apparatus and instruments
  • Biopsy
  • Endometrial brush biopsy
  • Endometrial neoplasms

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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  • Cite this

    Del Priore, G., Williams, R., Harbatkin, C. B., Wan, L. S., Mittal, K., & Yang, G. C. H. (2001). Endometrial brush biopsy for the diagnosis of endometrial cancer. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 46(5), 439-443.