Endoscopic Management of Upper Tract Urothelial Carcinoma in Patients With a History of Bladder Urothelial Carcinoma

Amy E. Krambeck, R. Houston Thompson, Christine M. Lohse, David E. Patterson, Joseph W. Segura, Horst Zincke, Daniel S. Elliott, Michael L. Blute

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Purpose: Endoscopic management of renal pelvis and ureteral urothelial carcinoma is gaining acceptance as a conservative treatment modality. Patients with a history of bladder urothelial carcinoma are at high risk for upper tract recurrence. We evaluate the role of endoscopic management of upper tract urothelial carcinoma in patients with a history of primary bladder urothelial carcinoma. Materials and Methods: We retrospectively reviewed 90 patients with a history of primary bladder urothelial carcinoma who underwent endoscopic treatment of localized upper tract urothelial carcinoma between 1983 and 2004. Results: Median patient age at diagnosis was 73 years (range 50 to 90). A total of 13 (14.4%) patients previously underwent cystectomy. With a median followup of 4.3 years (range 0.1 to 17), 105 upper tract urothelial carcinoma recurrences developed in 55 patients at a mean of 0.6 years (range 22 days to 5.9 years). Of these recurrences 76 were amenable to endoscopic management while 29 required nephroureterectomy. In 38 patients there were 91 bladder recurrences. At last followup 48 patients died, 17 of urothelial carcinoma at a median of 3.4 years (range 1 to 10). Cancer specific survival at 5 years for this cohort was 71.2%. Risk of death from urothelial carcinoma was significantly associated with stage (RR 3.23) and grade (RR 4.05) of upper tract urothelial carcinoma, imperative indication (RR 4.30), and treatment of bladder urothelial carcinoma with cystectomy (RR 3.34). Conclusions: Endoscopic management of upper tract urothelial carcinoma in patients with primary bladder urothelial carcinoma demonstrates a significant local recurrence rate. Furthermore, 5-year cancer specific survival is low. These patients represent a high risk cohort requiring strict ureteroscopic followup after endoscopic management is instituted.

Original languageEnglish (US)
Pages (from-to)1721-1726
Number of pages6
JournalJournal of Urology
Volume177
Issue number5
DOIs
StatePublished - May 1 2007
Externally publishedYes

Keywords

  • carcinoma
  • endoscopy
  • kidney neoplasms
  • transitional cell
  • urinary bladder neoplasms

ASJC Scopus subject areas

  • Urology

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    Krambeck, A. E., Thompson, R. H., Lohse, C. M., Patterson, D. E., Segura, J. W., Zincke, H., Elliott, D. S., & Blute, M. L. (2007). Endoscopic Management of Upper Tract Urothelial Carcinoma in Patients With a History of Bladder Urothelial Carcinoma. Journal of Urology, 177(5), 1721-1726. https://doi.org/10.1016/j.juro.2007.01.006