Endoscopic ultrasound and PDT for pancreatic cancer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Background and Aims: In a single-center, prospective, dose-escalation phase 1 study, patients with treatment-naïve locally advanced pancreatic cancer (LAPC) received intravenous porfimer sodium followed 2 days later by EUS-PDT. EUS-PDT was performed by puncture with a 19-gauge needle and insertion of a 1.0-cm light diffuser and illumination with a 630-nm light. A CT scan 18 days after PDT was done to assess for change in pancreatic necrosis. Nab-paclitaxel and gemcitabine were initiated 7 days after CT. Results: Twelve patients (mean age, 67 ± 6 years; 8 male) with tumors (mean diameter, 45.2 ± 12.9 mm) in the head and/or neck (8) or body and/or tail (4) underwent EUS-PDT. Compared with baseline imaging, increased volume and percentage of tumor necrosis were observed in 6 of 12 patients (50%) after EUS-PDT. No serious adverse events from PDT occurred. Conclusion: EUS-PDT for LAPC is technically feasible. Phase II studies are warranted.

Original languageEnglish (US)
Title of host publication17th International Photodynamic Association World Congress
EditorsTayyaba Hasan
PublisherSPIE
ISBN (Electronic)9781510628335
DOIs
StatePublished - Jan 1 2019
Event17th International Photodynamic Association World Congress 2019 - Cambridge, United States
Duration: Jun 28 2019Jul 4 2019

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11070
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

Conference17th International Photodynamic Association World Congress 2019
CountryUnited States
CityCambridge
Period6/28/197/4/19

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Dewitt, J. (2019). Endoscopic ultrasound and PDT for pancreatic cancer. In T. Hasan (Ed.), 17th International Photodynamic Association World Congress [110705Y] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11070). SPIE. https://doi.org/10.1117/12.2528591