Endoscopic ultrasound guided fine needle aspiration of the pancreas: Is pancreatitis a complication?

S. Ikenberry, F. Gress, R. Ness, S. Sherman, G. Lehman

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2 Scopus citations


Introduction: Endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) of the pancreas is being increasingly performed on patients with pancreatic masses. There have been no reported cases of pancreatitis following FNA of the pancreas. We have previously seen 2 cases of clinical pancreatitis following FNA of the pancreas. The aim of this study was to determine the frequency of chemical and clinical pancreatitis following EUS guided FNA of the pancreas. Methods: Data was prospectively collected on 19 patients. Serum amylase and lipase levels were measured immediately prior to and 2 hours post FNA. Patients were called 24-72 hours after FNA to inquire about increased pain, nausea, or vomiting suggesting clinical pancreatitis. Results: Pre- and post-FNA amylase levels were available for 17 patients. Pre-and post-FNA lipase levels were available for 16 patients Pre and Post EUS Guided FNA Serum Enzyme Levels Mean Pre Mean Post Mean Change CI P Value Amylase 52.9 58.9 6.0 -11.3, 23.4 .47 Lipase 198.9 303.6 104.8 -124.1, 107.3 .35 CI=Confidence Interval There was a mean increase in serum amylase and lipase levels. However, when matched pair analysis was performed, the differences were not statistically significant. There were no episodes of clinical pancreatitis Conclusion: This preliminary prospective study found no evidence of chemical or clinical pancreatitis. However, these findings could be secondary to a small sample size. Based on our retrospective review, further ongoing prospective studies are warranted to evaluate the true risk of pancreatitis from this technique.

Original languageEnglish (US)
Number of pages1
JournalGastrointestinal endoscopy
Issue number4
StatePublished - Jan 1 1996


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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