Endoscopic ultrasound in non-small cell lung cancer and negative mediastinum on computed tomography

Julia K. LeBlanc, Benedict M. Devereaux, Thomas F. Imperiale, Ken Kesler, John M. DeWitt, Oscar Cummings, Donato Ciaccia, Stuart Sherman, Praveen Mathur, Dewey Conces, Joann Brooks, Melissa Chriswell, Lawrence Einhorn, Edith Collins

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Despite technical advances in staging non-small cell lung cancer (NSCLC), accurate staging remains a challenge. Endoscopic ultrasound is useful in staging NSCLC when lymphadenopathy is present on a computed tomography (CT), but its role in the absence of lymphadenopathy on CT has not been well defined. Therefore, we sought to determine the clinical impact of endoscopic ultrasound (EUS) in staging NSCLC in absence of mediastinal lymphadenopathy on CT. Seventy-six patients with NSCLC with absence of mediastinal lymphadenopathy on CT were enrolled and followed prospectively. EUS-guided fine-needle aspiration was performed on sites that were suspicious for metastases. Surgical pathology after thoracotomy was used as the reference standard for assessing accuracy. Sixty-two (86%) patients underwent surgery, and 10 (13%) did not. EUS precluded surgery in 9 patients (12%) and influenced management in 18 (25%) of all patients in this study. EUS detected malignant mediastinal lymphadenopathy more frequently in patients with lower lobe and hilar cancers combined compared with upper lobe cancers (p = 0.004). EUS played a significant role in identifying patients with unresectable (N3) NSCLC when adenopathy was not present on CT imaging and appears to be more sensitive in detecting lymph node metastases in lower lobe and hilar NSCLC compared with upper lobe NSCLC.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalAmerican journal of respiratory and critical care medicine
Issue number2
StatePublished - Jan 15 2005
Externally publishedYes


  • Endoscopic ultrasound
  • Fine-needle aspiration
  • Mediastinal lymphadenopathy
  • Non-small cell lung cancer
  • Thoracotomy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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