Endoscopic valvuloplasty for GERD

Tomas Martinez-Serna, Richard E. Davis, Rodney Mason, Galen Perdikis, Charles J. Filipi, Glen Lehman, John Nigro, Patrice Watson

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background: The transoral, endoscopic route has been suggested as a possible approach for the correction of severe gastroesophageal reflux. Such a procedure would involve no mobilization of the cardia or other structures. The optimal placement, number, and configuration of sutures remains undefined. Methods: With the use of a previously developed endoscopic sewing machine, this study was undertaken in baboons with two suture arrangements immediately below the lower esophageal sphincter. A linear arrangement (group I) and a circular arrangement (group II) were compared. During the 6 months after the procedure, the animals were evaluated using manometry, fluoroscopic barium swallow, upper gastrointestinal endoscopy, and a pressure volume test. Results: A significant increase in lower esophageal sphincter length was demonstrated only in group II (p = 0.010). A significant increase in lower esophageal sphincter pressure was demonstrated only in group I animals (p = 0.008). The abdominal length increased in group I (p = 0.004) and group II (p = 0.004). The yield pressure and yield volume did not differ significantly from those measured previously in control animals. No evidence of reflux, stricture formation, esophagitis, or other pathology was noted. Conclusions: Some manometric parameters associated with gastroesophageal reflux are altered by the endoscopic placement of sutures below the gastroesophageal junction, with no associated serious complications.

Original languageEnglish
Pages (from-to)663-670
Number of pages8
JournalGastrointestinal Endoscopy
Volume52
Issue number5
StatePublished - 2000

Fingerprint

Lower Esophageal Sphincter
Gastroesophageal Reflux
Sutures
Pressure
Esophagogastric Junction
Cardia
Gastrointestinal Endoscopy
Esophagitis
Papio
Manometry
Barium
Deglutition
Pathologic Constriction
Pathology

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Martinez-Serna, T., Davis, R. E., Mason, R., Perdikis, G., Filipi, C. J., Lehman, G., ... Watson, P. (2000). Endoscopic valvuloplasty for GERD. Gastrointestinal Endoscopy, 52(5), 663-670.

Endoscopic valvuloplasty for GERD. / Martinez-Serna, Tomas; Davis, Richard E.; Mason, Rodney; Perdikis, Galen; Filipi, Charles J.; Lehman, Glen; Nigro, John; Watson, Patrice.

In: Gastrointestinal Endoscopy, Vol. 52, No. 5, 2000, p. 663-670.

Research output: Contribution to journalArticle

Martinez-Serna, T, Davis, RE, Mason, R, Perdikis, G, Filipi, CJ, Lehman, G, Nigro, J & Watson, P 2000, 'Endoscopic valvuloplasty for GERD', Gastrointestinal Endoscopy, vol. 52, no. 5, pp. 663-670.
Martinez-Serna T, Davis RE, Mason R, Perdikis G, Filipi CJ, Lehman G et al. Endoscopic valvuloplasty for GERD. Gastrointestinal Endoscopy. 2000;52(5):663-670.
Martinez-Serna, Tomas ; Davis, Richard E. ; Mason, Rodney ; Perdikis, Galen ; Filipi, Charles J. ; Lehman, Glen ; Nigro, John ; Watson, Patrice. / Endoscopic valvuloplasty for GERD. In: Gastrointestinal Endoscopy. 2000 ; Vol. 52, No. 5. pp. 663-670.
@article{5771ea2d93c1465695a3efbb3f0f3a4f,
title = "Endoscopic valvuloplasty for GERD",
abstract = "Background: The transoral, endoscopic route has been suggested as a possible approach for the correction of severe gastroesophageal reflux. Such a procedure would involve no mobilization of the cardia or other structures. The optimal placement, number, and configuration of sutures remains undefined. Methods: With the use of a previously developed endoscopic sewing machine, this study was undertaken in baboons with two suture arrangements immediately below the lower esophageal sphincter. A linear arrangement (group I) and a circular arrangement (group II) were compared. During the 6 months after the procedure, the animals were evaluated using manometry, fluoroscopic barium swallow, upper gastrointestinal endoscopy, and a pressure volume test. Results: A significant increase in lower esophageal sphincter length was demonstrated only in group II (p = 0.010). A significant increase in lower esophageal sphincter pressure was demonstrated only in group I animals (p = 0.008). The abdominal length increased in group I (p = 0.004) and group II (p = 0.004). The yield pressure and yield volume did not differ significantly from those measured previously in control animals. No evidence of reflux, stricture formation, esophagitis, or other pathology was noted. Conclusions: Some manometric parameters associated with gastroesophageal reflux are altered by the endoscopic placement of sutures below the gastroesophageal junction, with no associated serious complications.",
author = "Tomas Martinez-Serna and Davis, {Richard E.} and Rodney Mason and Galen Perdikis and Filipi, {Charles J.} and Glen Lehman and John Nigro and Patrice Watson",
year = "2000",
language = "English",
volume = "52",
pages = "663--670",
journal = "Gastrointestinal Endoscopy",
issn = "0016-5107",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Endoscopic valvuloplasty for GERD

AU - Martinez-Serna, Tomas

AU - Davis, Richard E.

AU - Mason, Rodney

AU - Perdikis, Galen

AU - Filipi, Charles J.

AU - Lehman, Glen

AU - Nigro, John

AU - Watson, Patrice

PY - 2000

Y1 - 2000

N2 - Background: The transoral, endoscopic route has been suggested as a possible approach for the correction of severe gastroesophageal reflux. Such a procedure would involve no mobilization of the cardia or other structures. The optimal placement, number, and configuration of sutures remains undefined. Methods: With the use of a previously developed endoscopic sewing machine, this study was undertaken in baboons with two suture arrangements immediately below the lower esophageal sphincter. A linear arrangement (group I) and a circular arrangement (group II) were compared. During the 6 months after the procedure, the animals were evaluated using manometry, fluoroscopic barium swallow, upper gastrointestinal endoscopy, and a pressure volume test. Results: A significant increase in lower esophageal sphincter length was demonstrated only in group II (p = 0.010). A significant increase in lower esophageal sphincter pressure was demonstrated only in group I animals (p = 0.008). The abdominal length increased in group I (p = 0.004) and group II (p = 0.004). The yield pressure and yield volume did not differ significantly from those measured previously in control animals. No evidence of reflux, stricture formation, esophagitis, or other pathology was noted. Conclusions: Some manometric parameters associated with gastroesophageal reflux are altered by the endoscopic placement of sutures below the gastroesophageal junction, with no associated serious complications.

AB - Background: The transoral, endoscopic route has been suggested as a possible approach for the correction of severe gastroesophageal reflux. Such a procedure would involve no mobilization of the cardia or other structures. The optimal placement, number, and configuration of sutures remains undefined. Methods: With the use of a previously developed endoscopic sewing machine, this study was undertaken in baboons with two suture arrangements immediately below the lower esophageal sphincter. A linear arrangement (group I) and a circular arrangement (group II) were compared. During the 6 months after the procedure, the animals were evaluated using manometry, fluoroscopic barium swallow, upper gastrointestinal endoscopy, and a pressure volume test. Results: A significant increase in lower esophageal sphincter length was demonstrated only in group II (p = 0.010). A significant increase in lower esophageal sphincter pressure was demonstrated only in group I animals (p = 0.008). The abdominal length increased in group I (p = 0.004) and group II (p = 0.004). The yield pressure and yield volume did not differ significantly from those measured previously in control animals. No evidence of reflux, stricture formation, esophagitis, or other pathology was noted. Conclusions: Some manometric parameters associated with gastroesophageal reflux are altered by the endoscopic placement of sutures below the gastroesophageal junction, with no associated serious complications.

UR - http://www.scopus.com/inward/record.url?scp=0033764644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033764644&partnerID=8YFLogxK

M3 - Article

VL - 52

SP - 663

EP - 670

JO - Gastrointestinal Endoscopy

JF - Gastrointestinal Endoscopy

SN - 0016-5107

IS - 5

ER -