Endoscopic valvuloplasty for GERD

Tomas Martinez-Serna, Richard E. Davis, Rodney Mason, Galen Perdikis, Charles J. Filipi, Glen Lehman, John Nigro, Patrice Watson

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Background: The transoral, endoscopic route has been suggested as a possible approach for the correction of severe gastroesophageal reflux. Such a procedure would involve no mobilization of the cardia or other structures. The optimal placement, number, and configuration of sutures remains undefined. Methods: With the use of a previously developed endoscopic sewing machine, this study was undertaken in baboons with two suture arrangements immediately below the lower esophageal sphincter. A linear arrangement (group I) and a circular arrangement (group II) were compared. During the 6 months after the procedure, the animals were evaluated using manometry, fluoroscopic barium swallow, upper gastrointestinal endoscopy, and a pressure volume test. Results: A significant increase in lower esophageal sphincter length was demonstrated only in group II (p = 0.010). A significant increase in lower esophageal sphincter pressure was demonstrated only in group I animals (p = 0.008). The abdominal length increased in group I (p = 0.004) and group II (p = 0.004). The yield pressure and yield volume did not differ significantly from those measured previously in control animals. No evidence of reflux, stricture formation, esophagitis, or other pathology was noted. Conclusions: Some manometric parameters associated with gastroesophageal reflux are altered by the endoscopic placement of sutures below the gastroesophageal junction, with no associated serious complications.

Original languageEnglish (US)
Pages (from-to)663-670
Number of pages8
JournalGastrointestinal endoscopy
Volume52
Issue number5
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

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    Martinez-Serna, T., Davis, R. E., Mason, R., Perdikis, G., Filipi, C. J., Lehman, G., Nigro, J., & Watson, P. (2000). Endoscopic valvuloplasty for GERD. Gastrointestinal endoscopy, 52(5), 663-670. https://doi.org/10.1067/mge.2000.109871