Endothelial cell conditioned media mediated regulation of glutamine synthetase activity in glial cells

Polyxenie E. Spoerri, Maria B. Grant, Julissa Gomez, Antonia Vernadakis

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The responsiveness of late passage C-6 glial cells to human retinal endothelial cell-conditioned medium (HREC-CM) was examined using glutamine synthetase (GS) activity as test parameter. Treatment with 50% or 100% HREC- CM for 4-5 days slightly affected the morphology but significantly increased GS activity. Increased glial GS activity induced by vascular endothelial cells is of relevance in preventing extracellular glutamate toxicity and regulating the brain/retinal blood barrier.

Original languageEnglish (US)
Pages (from-to)205-208
Number of pages4
JournalDevelopmental Brain Research
Volume104
Issue number1-2
DOIs
StatePublished - Dec 19 1997

Keywords

  • Brain/retinal blood barrier
  • C-6 glioma
  • Glutamate
  • Growth factor
  • Human retinal endothelial cell
  • Tissue culture

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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