Endothelial colony-forming cell role in neoangiogenesis and tissue repair

Paul J. Critser, Mervin Yoder

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Purpose of review: Patients suffering from vascular disease often have impaired angiogenic ability contributing to impaired tissue repair. One potential therapy is to deliver cells that can aid in angiogenesis. This review will discuss the ability of endothelial progenitor cells (EPCs), which have been reported to contribute to neoangiogenesis in both physiological and pathological conditions, to contribute to neoangiogenesis in tissue repair. Recent findings: In recent years, various reports have described conflicting roles for EPC in vessel formation. Currently there are three different assays for outgrowth of EPC all resulting in the isolation of different cell populations. This confusion is partially due to limited functional characterization of putative EPC populations. One population, endothelial colony-forming cell (ECFC), has been shown to possess all the characteristics of a true endothelial progenitor. Summary: The review overviews the role of putative EPC populations in angiogenesis and tissue repair. Whereas all EPC populations have been shown to play a role in angiogenesis, only ECFC have demonstrated the ability to form de-novo blood vessels in vivo. Additionally ECFC have been shown to play a role in neovascularization in several preclinical rodent models suggesting that it may be an excellent cell source for treatment of patients with diminished vascular function.

Original languageEnglish
Pages (from-to)68-72
Number of pages5
JournalCurrent Opinion in Organ Transplantation
Volume15
Issue number1
DOIs
StatePublished - Feb 2010

Fingerprint

Population
Blood Vessels
Cell Separation
Vascular Diseases
Endothelial Progenitor Cells
Rodentia
Therapeutics

Keywords

  • Angiogenesis
  • Endothelial colony-forming cell
  • Endothelial progenitor cell
  • Wound healing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

Cite this

Endothelial colony-forming cell role in neoangiogenesis and tissue repair. / Critser, Paul J.; Yoder, Mervin.

In: Current Opinion in Organ Transplantation, Vol. 15, No. 1, 02.2010, p. 68-72.

Research output: Contribution to journalArticle

@article{8a949973f6694c36a2fdfb74141a6a9b,
title = "Endothelial colony-forming cell role in neoangiogenesis and tissue repair",
abstract = "Lippincott Williams & Wilkins.",
keywords = "Angiogenesis, Endothelial colony-forming cell, Endothelial progenitor cell, Wound healing",
author = "Critser, {Paul J.} and Mervin Yoder",
year = "2010",
month = "2",
doi = "10.1097/MOT.0b013e32833454b5",
language = "English",
volume = "15",
pages = "68--72",
journal = "Current Opinion in Organ Transplantation",
issn = "1087-2418",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Endothelial colony-forming cell role in neoangiogenesis and tissue repair

AU - Critser, Paul J.

AU - Yoder, Mervin

PY - 2010/2

Y1 - 2010/2

N2 - Lippincott Williams & Wilkins.

AB - Lippincott Williams & Wilkins.

KW - Angiogenesis

KW - Endothelial colony-forming cell

KW - Endothelial progenitor cell

KW - Wound healing

UR - http://www.scopus.com/inward/record.url?scp=75749100300&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75749100300&partnerID=8YFLogxK

U2 - 10.1097/MOT.0b013e32833454b5

DO - 10.1097/MOT.0b013e32833454b5

M3 - Article

VL - 15

SP - 68

EP - 72

JO - Current Opinion in Organ Transplantation

JF - Current Opinion in Organ Transplantation

SN - 1087-2418

IS - 1

ER -