Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases

Kent W. Christopherson, Antoinette F. Hood, Jeffrey Travers, Heather Ramsey, Robert A. Hromas

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The signals that mediate T-cell infiltration during T-cell autoimmune diseases are poorly understood. The chemokine CCL21 (originally isolated by us and others as Exodus-2/6Ckine/SLC/TCA4) is highly potent and highly specific for stimulating T-cell migration. However, it is thought to be expressed only in secondary lymphoid organs, directing naive T cells to areas of antigen presentation. It is not thought to play a role in T-cell effector function during a normal immune response. In this study we tested the expression of T-cell chemokines and their receptors during T-cell autoimmune infiltrative skin diseases. By using immunohistology it was found that the expression of CCL21 but not CCL19 or 20 was highly induced in endothelial cells of T-cell autoimmune diseases. The receptor for CCL21, CCR7, was also found to be highly expressed on the infiltrating T cells, most of which expressed the memory CD45Ro phenotype. These data imply that the usual loss of CCL21 responsiveness in the normal development of memory T-cell effector function does not hold for autoimmune skin diseases.

Original languageEnglish (US)
Pages (from-to)801-806
Number of pages6
JournalBlood
Volume101
Issue number3
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

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Chemokine CCL21
T-cells
Autoimmune Diseases
T-Lymphocytes
Skin Diseases
CCR7 Receptors
Skin
Data storage equipment
Chemokine Receptors
Endothelial cells
Antigen Presentation
Infiltration
Cell Movement

ASJC Scopus subject areas

  • Hematology

Cite this

Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases. / Christopherson, Kent W.; Hood, Antoinette F.; Travers, Jeffrey; Ramsey, Heather; Hromas, Robert A.

In: Blood, Vol. 101, No. 3, 01.02.2003, p. 801-806.

Research output: Contribution to journalArticle

Christopherson, KW, Hood, AF, Travers, J, Ramsey, H & Hromas, RA 2003, 'Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases', Blood, vol. 101, no. 3, pp. 801-806. https://doi.org/10.1182/blood-2002-05-1586
Christopherson, Kent W. ; Hood, Antoinette F. ; Travers, Jeffrey ; Ramsey, Heather ; Hromas, Robert A. / Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases. In: Blood. 2003 ; Vol. 101, No. 3. pp. 801-806.
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