Endothelial progenitor cell: A blood cell by many other names may serve similar functions

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The first reports of circulating cells that displayed the capacity to repair and regenerate damaged vascular endothelial cells as progenitor cells for the endothelial lineage (EPC) were met with great enthusiasm. However, the cell surface antigens and colony assays used to identify the putative EPC were soon found to overlap with those of the hematopoietic lineage. Over the past decade, it has become clear that specific hematopoietic subsets play important roles in vascular repair and regeneration. This review will provide some overview of the hematopoietic hierarchy and methods to segregate distinct subsets that may provide clarity in identifying the proangiogenic hematopoietic cells. This review will not discuss those circulating viable endothelial cells that play a role as EPC and are called endothelia colony-forming cells. The review will conclude with identification of some roadblocks to progress in the field of identification of circulating cells that participate in vascular repair and regeneration.

Original languageEnglish
Pages (from-to)285-295
Number of pages11
JournalJournal of Molecular Medicine
Volume91
Issue number3
DOIs
StatePublished - Mar 2013

Fingerprint

Names
Blood Cells
Blood Vessels
Regeneration
Endothelial Cells
Cell Lineage
Surface Antigens
Endothelium
Stem Cells
Endothelial Progenitor Cells
erucylphosphocholine

Keywords

  • Endothelial progenitor cell
  • Proangiogenic hematopoietic cell
  • Vasculogenesis

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

Cite this

Endothelial progenitor cell : A blood cell by many other names may serve similar functions. / Yoder, Mervin.

In: Journal of Molecular Medicine, Vol. 91, No. 3, 03.2013, p. 285-295.

Research output: Contribution to journalArticle

@article{4497073b4c864c28912ab9a72fd52a14,
title = "Endothelial progenitor cell: A blood cell by many other names may serve similar functions",
abstract = "The first reports of circulating cells that displayed the capacity to repair and regenerate damaged vascular endothelial cells as progenitor cells for the endothelial lineage (EPC) were met with great enthusiasm. However, the cell surface antigens and colony assays used to identify the putative EPC were soon found to overlap with those of the hematopoietic lineage. Over the past decade, it has become clear that specific hematopoietic subsets play important roles in vascular repair and regeneration. This review will provide some overview of the hematopoietic hierarchy and methods to segregate distinct subsets that may provide clarity in identifying the proangiogenic hematopoietic cells. This review will not discuss those circulating viable endothelial cells that play a role as EPC and are called endothelia colony-forming cells. The review will conclude with identification of some roadblocks to progress in the field of identification of circulating cells that participate in vascular repair and regeneration.",
keywords = "Endothelial progenitor cell, Proangiogenic hematopoietic cell, Vasculogenesis",
author = "Mervin Yoder",
year = "2013",
month = "3",
doi = "10.1007/s00109-013-1002-8",
language = "English",
volume = "91",
pages = "285--295",
journal = "Journal of Molecular Medicine",
issn = "0946-2716",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Endothelial progenitor cell

T2 - A blood cell by many other names may serve similar functions

AU - Yoder, Mervin

PY - 2013/3

Y1 - 2013/3

N2 - The first reports of circulating cells that displayed the capacity to repair and regenerate damaged vascular endothelial cells as progenitor cells for the endothelial lineage (EPC) were met with great enthusiasm. However, the cell surface antigens and colony assays used to identify the putative EPC were soon found to overlap with those of the hematopoietic lineage. Over the past decade, it has become clear that specific hematopoietic subsets play important roles in vascular repair and regeneration. This review will provide some overview of the hematopoietic hierarchy and methods to segregate distinct subsets that may provide clarity in identifying the proangiogenic hematopoietic cells. This review will not discuss those circulating viable endothelial cells that play a role as EPC and are called endothelia colony-forming cells. The review will conclude with identification of some roadblocks to progress in the field of identification of circulating cells that participate in vascular repair and regeneration.

AB - The first reports of circulating cells that displayed the capacity to repair and regenerate damaged vascular endothelial cells as progenitor cells for the endothelial lineage (EPC) were met with great enthusiasm. However, the cell surface antigens and colony assays used to identify the putative EPC were soon found to overlap with those of the hematopoietic lineage. Over the past decade, it has become clear that specific hematopoietic subsets play important roles in vascular repair and regeneration. This review will provide some overview of the hematopoietic hierarchy and methods to segregate distinct subsets that may provide clarity in identifying the proangiogenic hematopoietic cells. This review will not discuss those circulating viable endothelial cells that play a role as EPC and are called endothelia colony-forming cells. The review will conclude with identification of some roadblocks to progress in the field of identification of circulating cells that participate in vascular repair and regeneration.

KW - Endothelial progenitor cell

KW - Proangiogenic hematopoietic cell

KW - Vasculogenesis

UR - http://www.scopus.com/inward/record.url?scp=84875728393&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875728393&partnerID=8YFLogxK

U2 - 10.1007/s00109-013-1002-8

DO - 10.1007/s00109-013-1002-8

M3 - Article

C2 - 23371317

AN - SCOPUS:84875728393

VL - 91

SP - 285

EP - 295

JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

SN - 0946-2716

IS - 3

ER -