Endothelial progenitor cell: Ongoing controversy for defining these cells and their role in neoangiogenesis in the murine system

Research output: Contribution to journalReview article

72 Scopus citations

Abstract

PURPOSE OF REVIEW: We highlight some recent high-profile articles in which the study results and interpretations, upon comparison, convey the controversy and disparate views prevalent in the field when defining the role of murine bone marrow-derived endothelial progenitor cells in the process of tumor neoangiogenesis. RECENT FINDINGS: Highlighted articles identify a critical role for these cells in promoting the angiogenic switch for growth of metastatic tumors or find no role at all for these circulating cells as engrafting cells in vascular endothelium or as promoters of tumor growth. We suggest potential strategies to further document cell identities as a guide for future studies and provide some alternative interpretations of the published studies highlighted in this review that, if considered, may diminish the current polar views. SUMMARY: To fully appreciate the orchestrated cellular events participating in new vessel formation in the tumor microenvironment, better methods of cell identification and functional validation will be necessary to specify which cells in which tumors are facilitating and forming new vessels in which tissues at which stage of the disease.

Original languageEnglish (US)
Pages (from-to)269-273
Number of pages5
JournalCurrent opinion in hematology
Volume16
Issue number4
DOIs
StatePublished - Jul 1 2009

Keywords

  • Circulating endothelial cell
  • Endothelial colony-forming cell
  • Endothelial progenitor cell
  • Hematopoietic progenitor cell
  • Neoangiogenesis

ASJC Scopus subject areas

  • Hematology

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