Endothelial progenitor cells: Identity defined?

Frank Timmermans, Jean Plum, Mervin Yoder, David Ingram, Bart Vandekerckhove, Jamie Case

Research output: Contribution to journalArticle

388 Citations (Scopus)

Abstract

In the past decade, researchers have gained important insights on the role of bone marrow (BM)-derived cells in adult neovascularization. A subset of BM-derived cells, called endothelial progenitor cells (EPCs), has been of particular interest, as these cells were suggested to home to sites of neovascularization and neoendothelialization and differentiate into endothelial cells (ECs) in situ, a process referred to as postnatal vasculogenesis. Therefore, EPCs were proposed as a potential regenerative tool for treating human vascular disease and a possible target to restrict vessel growth in tumour pathology. However, conflicting results have been reported in the field, and the identification, characterization, and exact role of EPCs in vascular biology is still a subject of much discussion. The focus of this review is on the controversial issues in the field of EPCs which are related to the lack of a unique EPC marker, identification challenges related to the paucity of EPCs in the circulation, and the important phenotypical and functional overlap between EPCs, haematopoietic cells and mature ECs. We also discuss our recent findings on the origin of endothelial outgrowth cells (EOCs), showing that this in vitro defined EC population does not originate from circulating CD133+ cells or CD45+ haematopoietic cells.

Original languageEnglish
Pages (from-to)87-102
Number of pages16
JournalJournal of Cellular and Molecular Medicine
Volume13
Issue number1
DOIs
StatePublished - Jan 2009

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Endothelial Cells
Bone Marrow Cells
Endothelial Progenitor Cells
Vascular Diseases
Blood Vessels
Research Personnel
Pathology
Growth
Population
Neoplasms

Keywords

  • CD133
  • CD34
  • CD45
  • Endothelial progenitor cells
  • Haematopoietic cells

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

Cite this

Endothelial progenitor cells : Identity defined? / Timmermans, Frank; Plum, Jean; Yoder, Mervin; Ingram, David; Vandekerckhove, Bart; Case, Jamie.

In: Journal of Cellular and Molecular Medicine, Vol. 13, No. 1, 01.2009, p. 87-102.

Research output: Contribution to journalArticle

Timmermans, Frank ; Plum, Jean ; Yoder, Mervin ; Ingram, David ; Vandekerckhove, Bart ; Case, Jamie. / Endothelial progenitor cells : Identity defined?. In: Journal of Cellular and Molecular Medicine. 2009 ; Vol. 13, No. 1. pp. 87-102.
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