Endothelial Stem and Progenitor Cells for Regenerative Medicine

Kimihiko Banno, Mervin C. Yoder

Research output: Contribution to journalReview article

Abstract

Purpose of Review: Vascular endothelial stem cell (VESC) and progenitor cell are emerging as local resident regulators of vascular endothelial repair and replacement in mammalian subjects. However, widely recognized and accepted standard measures of stem cell function have yet to be published and, thus, we summarize some recent evidence that VESCs demonstrate stem cell properties in the process of endothelial cell (EC) lineage emergence, repair, and regeneration. Recent Findings: Some rare resident ECs have been identified that are quiescent and reside within blood vessels but are activated and proliferate in response to injury. Transcriptome analyses of these ECs at a single cell level are providing new insights into VESC identity, including tissue specific EC heterogeneity. Summary: Blood vessels and circulating blood contain rare immature ECs that display stem cell potential. Continuous efforts to define their precise location, origin, surface marker, and molecular signatures would enhance current approaches for purification of cells that would enable us to build new vessels for regenerative medicine.

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalCurrent Stem Cell Reports
Volume5
Issue number3
DOIs
StatePublished - Sep 15 2019

Keywords

  • Endothelial colony-forming cell (ECFC)
  • Endothelial progenitor cell (EPC)
  • Vascular endothelial stem cell (VESC)

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology
  • Cell Biology

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