Endotoxemia and the host systemic response during experimental gingivitis

Vivian Y. Wahaidi, Michael Kowolik, George J. Eckert, Dominique M. Galli

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aim: To assess endotoxemia episodes and subsequent changes in serum inflammatory biomarkers using the experimental gingivitis model. Materials and Methods: Data from 50 healthy black and white adult males and females were compared for serum concentrations of endotoxin, and serum biomarkers [neutrophil oxidative activity, interleukin (IL)-1β, IL-6, IL-8, C-reactive protein (CRP), and fibrinogen] at baseline, at 3 weeks of experimental gingivitis, and after 2 weeks of recovery. Means were compared using repeated measures analysis of variance. Results: Endotoxemia was reported in 56% of the serum samples at 3 weeks of induced gingivitis. At 2 weeks of recovery, endotoxin levels decreased to levels similar to those reported at baseline. Neutrophil oxidative activity increased significantly following 3 weeks of gingivitis versus baseline (p

Original languageEnglish (US)
Pages (from-to)412-417
Number of pages6
JournalJournal of Clinical Periodontology
Volume38
Issue number5
DOIs
StatePublished - May 2011

Fingerprint

Gingivitis
Endotoxemia
Serum
Endotoxins
Neutrophils
Biomarkers
Interleukin-8
Interleukin-1
C-Reactive Protein
Fibrinogen
Interleukin-6
Analysis of Variance
Theoretical Models

Keywords

  • acute-phase proteins
  • cytokines
  • dental plaque
  • endotoxin
  • experimental gingivitis
  • inflammatory response
  • neutrophils

ASJC Scopus subject areas

  • Periodontics

Cite this

Endotoxemia and the host systemic response during experimental gingivitis. / Wahaidi, Vivian Y.; Kowolik, Michael; Eckert, George J.; Galli, Dominique M.

In: Journal of Clinical Periodontology, Vol. 38, No. 5, 05.2011, p. 412-417.

Research output: Contribution to journalArticle

Wahaidi, Vivian Y. ; Kowolik, Michael ; Eckert, George J. ; Galli, Dominique M. / Endotoxemia and the host systemic response during experimental gingivitis. In: Journal of Clinical Periodontology. 2011 ; Vol. 38, No. 5. pp. 412-417.
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