Abstract
Aim: To assess endotoxemia episodes and subsequent changes in serum inflammatory biomarkers using the experimental gingivitis model. Materials and Methods: Data from 50 healthy black and white adult males and females were compared for serum concentrations of endotoxin, and serum biomarkers [neutrophil oxidative activity, interleukin (IL)-1β, IL-6, IL-8, C-reactive protein (CRP), and fibrinogen] at baseline, at 3 weeks of experimental gingivitis, and after 2 weeks of recovery. Means were compared using repeated measures analysis of variance. Results: Endotoxemia was reported in 56% of the serum samples at 3 weeks of induced gingivitis. At 2 weeks of recovery, endotoxin levels decreased to levels similar to those reported at baseline. Neutrophil oxidative activity increased significantly following 3 weeks of gingivitis versus baseline (p
| Original language | English (US) |
|---|---|
| Pages (from-to) | 412-417 |
| Number of pages | 6 |
| Journal | Journal of Clinical Periodontology |
| Volume | 38 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 2011 |
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Keywords
- acute-phase proteins
- cytokines
- dental plaque
- endotoxin
- experimental gingivitis
- inflammatory response
- neutrophils
ASJC Scopus subject areas
- Periodontics
Cite this
Endotoxemia and the host systemic response during experimental gingivitis. / Wahaidi, Vivian Y.; Kowolik, Michael; Eckert, George J.; Galli, Dominique M.
In: Journal of Clinical Periodontology, Vol. 38, No. 5, 05.2011, p. 412-417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endotoxemia and the host systemic response during experimental gingivitis
AU - Wahaidi, Vivian Y.
AU - Kowolik, Michael
AU - Eckert, George J.
AU - Galli, Dominique M.
PY - 2011/5
Y1 - 2011/5
N2 - Aim: To assess endotoxemia episodes and subsequent changes in serum inflammatory biomarkers using the experimental gingivitis model. Materials and Methods: Data from 50 healthy black and white adult males and females were compared for serum concentrations of endotoxin, and serum biomarkers [neutrophil oxidative activity, interleukin (IL)-1β, IL-6, IL-8, C-reactive protein (CRP), and fibrinogen] at baseline, at 3 weeks of experimental gingivitis, and after 2 weeks of recovery. Means were compared using repeated measures analysis of variance. Results: Endotoxemia was reported in 56% of the serum samples at 3 weeks of induced gingivitis. At 2 weeks of recovery, endotoxin levels decreased to levels similar to those reported at baseline. Neutrophil oxidative activity increased significantly following 3 weeks of gingivitis versus baseline (p
AB - Aim: To assess endotoxemia episodes and subsequent changes in serum inflammatory biomarkers using the experimental gingivitis model. Materials and Methods: Data from 50 healthy black and white adult males and females were compared for serum concentrations of endotoxin, and serum biomarkers [neutrophil oxidative activity, interleukin (IL)-1β, IL-6, IL-8, C-reactive protein (CRP), and fibrinogen] at baseline, at 3 weeks of experimental gingivitis, and after 2 weeks of recovery. Means were compared using repeated measures analysis of variance. Results: Endotoxemia was reported in 56% of the serum samples at 3 weeks of induced gingivitis. At 2 weeks of recovery, endotoxin levels decreased to levels similar to those reported at baseline. Neutrophil oxidative activity increased significantly following 3 weeks of gingivitis versus baseline (p
KW - acute-phase proteins
KW - cytokines
KW - dental plaque
KW - endotoxin
KW - experimental gingivitis
KW - inflammatory response
KW - neutrophils
UR - http://www.scopus.com/inward/record.url?scp=79954630475&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954630475&partnerID=8YFLogxK
U2 - 10.1111/j.1600-051X.2011.01710.x
DO - 10.1111/j.1600-051X.2011.01710.x
M3 - Article
C2 - 21320151
AN - SCOPUS:79954630475
VL - 38
SP - 412
EP - 417
JO - Journal of Clinical Periodontology
JF - Journal of Clinical Periodontology
SN - 0303-6979
IS - 5
ER -