Endpoints for mouse abdominal tumor models: Refinement of current criteria

Eden V. Paster, Kimberly A. Villines, Debra Hickman

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Accurate, rapid, and noninvasive health assessments are required to establish more appropriate endpoints in mouse cancer models where tumor size is not easily measured. We evaluated potential endpoints in mice with experimentally induced peritoneal lymphoma, an abdominal tumor model, by comparing body weight, body condition, and behavior with those of a control group of mice not developing lymphoma. Our hypothesis was that body weight would increase or plateau, whereas body condition and behavioral scores would decrease, as disease progressed. Results indicated that body weight did not differ significantly between the control and experimental groups, but the experimental group experienced significant decreases in both body condition and behavioral scores. Our results support the use of body condition and behavioral scoring as adjunctive assessment methods for mice involved in abdominal lymphoma tumor studies in which health may decline despite an increase or plateau in body weight.

Original languageEnglish
Pages (from-to)234-241
Number of pages8
JournalComparative Medicine
Volume59
Issue number3
StatePublished - Jun 2009

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endpoints
body condition
Tumors
lymphoma
Body Weight
Lymphoma
neoplasms
body weight
mice
Health
Neoplasms
plateaus
Control Groups
methodology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Endpoints for mouse abdominal tumor models : Refinement of current criteria. / Paster, Eden V.; Villines, Kimberly A.; Hickman, Debra.

In: Comparative Medicine, Vol. 59, No. 3, 06.2009, p. 234-241.

Research output: Contribution to journalArticle

Paster, Eden V. ; Villines, Kimberly A. ; Hickman, Debra. / Endpoints for mouse abdominal tumor models : Refinement of current criteria. In: Comparative Medicine. 2009 ; Vol. 59, No. 3. pp. 234-241.
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