Energized configurations of heart mitochondria in situ

Robert A. Harris, Charles H. Williams, Monya Caldwell, David E. Green, Enrique Valdivia

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Abstract

Changes in the configurational state of the cristal membranes of rat heart mitochondria within the living cell can be induced by imposing energizing conditions. An exact correlation has been established between the configurational states of the cristal membrane and the energy states of the mitochondrion. The configurational changes observed in mitochondria in situ are comparable to those established for beef heart mitochondria in vitro and are consistent with the postulate of the conformational basis of energy transductions in membrane systems. The formation of paracrystalline arrays is one of the noteworthy features of configurational changes of mitochondria in situ.

Original languageEnglish (US)
Pages (from-to)700-702
Number of pages3
JournalScience
Volume165
Issue number3894
DOIs
StatePublished - Jan 1 1969

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Harris, R. A., Williams, C. H., Caldwell, M., Green, D. E., & Valdivia, E. (1969). Energized configurations of heart mitochondria in situ. Science, 165(3894), 700-702. https://doi.org/10.1126/science.165.3894.700