Sepsis and SIRS are characterised by increased hepato-splanchnic blood flow and oxygen transport due to hypermetabolism with enhanced oxygen uptake. This regional hypermetabolism may be associated with a mismatch of oxygen availability and demand potentially resulting in a pathological splanchnic oxygen uptake/supply dependency. It has been hypothesised that splanchnic hypermetabolism is due to increased hepatic gluconeogenesis which is caused by accelerated lactate uptake as a result of increased release from the peripheral tissues. This increased precursor efflux is triggered by cytokines. The response of splanchnic haemodynamics and oxygen kinetics, however, to therapeutic interventions does not necessarily parallel that of the different metabolic pathways. Therefore, the understanding of both tissue perfusion and oxygenation as well as metabolism is pivotal for evaluating resuscitative efforts and therapeutic strategies in intensive-care medicine.
|Translated title of the contribution||Energy Status and Splanchnic Function in Sepsis and Sys- Temic Inflammatory Response Syndrome (SIRS)|
|Number of pages||3|
|State||Published - Dec 1 1998|
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics