Energiestatus und Splanchnikusfunktion bei Sepsis und SIRS

Translated title of the contribution: Energy Status and Splanchnic Function in Sepsis and Sys- Temic Inflammatory Response Syndrome (SIRS)

Karl Träger, Karen Rieger, Peter Radermacher, Alexander Brinkmann

Research output: Contribution to journalArticle

Abstract

Sepsis and SIRS are characterised by increased hepato-splanchnic blood flow and oxygen transport due to hypermetabolism with enhanced oxygen uptake. This regional hypermetabolism may be associated with a mismatch of oxygen availability and demand potentially resulting in a pathological splanchnic oxygen uptake/supply dependency. It has been hypothesised that splanchnic hypermetabolism is due to increased hepatic gluconeogenesis which is caused by accelerated lactate uptake as a result of increased release from the peripheral tissues. This increased precursor efflux is triggered by cytokines. The response of splanchnic haemodynamics and oxygen kinetics, however, to therapeutic interventions does not necessarily parallel that of the different metabolic pathways. Therefore, the understanding of both tissue perfusion and oxygenation as well as metabolism is pivotal for evaluating resuscitative efforts and therapeutic strategies in intensive-care medicine.

Original languageGerman
Pages (from-to)63-65
Number of pages3
JournalAktuelle Ernahrungsmedizin Klinik und Praxis
Volume23
Issue number2
StatePublished - 1998
Externally publishedYes

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Systemic Inflammatory Response Syndrome
Viscera
Sepsis
Oxygen
Gluconeogenesis
Critical Care
Metabolic Networks and Pathways
Lactic Acid
Perfusion
Hemodynamics
Medicine
Cytokines
Liver
Therapeutics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Energiestatus und Splanchnikusfunktion bei Sepsis und SIRS. / Träger, Karl; Rieger, Karen; Radermacher, Peter; Brinkmann, Alexander.

In: Aktuelle Ernahrungsmedizin Klinik und Praxis, Vol. 23, No. 2, 1998, p. 63-65.

Research output: Contribution to journalArticle

Träger, K, Rieger, K, Radermacher, P & Brinkmann, A 1998, 'Energiestatus und Splanchnikusfunktion bei Sepsis und SIRS', Aktuelle Ernahrungsmedizin Klinik und Praxis, vol. 23, no. 2, pp. 63-65.
Träger, Karl ; Rieger, Karen ; Radermacher, Peter ; Brinkmann, Alexander. / Energiestatus und Splanchnikusfunktion bei Sepsis und SIRS. In: Aktuelle Ernahrungsmedizin Klinik und Praxis. 1998 ; Vol. 23, No. 2. pp. 63-65.
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