Enhanced endocardial visualization with noncontrast harmonic imaging during stress echocardiography

D. G. Skolnick, S. G. Sawada, H. Feigenbaum, D. S. Segar

Research output: Contribution to journalArticle

29 Scopus citations


The diagnostic value of echocardiography hinges on the reader's ability to adequately visualize the endocardium of the left ventricle. This study was designed to evaluate the potential benefit of noncontrast harmonic imaging to enhance endocardial visualization. Eighty consecutive outpatients who underwent treadmill stress echocardiography were randomly assigned to either fundamental or harmonic imaging. The echoes were interpreted by 2 experienced readers. Compared with fundamental imaging, harmonic imaging of tissue improved the overall endocardial visualization score by 35% and 21% for readers 1 and 2, respectively (P < .001). Harmonic imaging also reduced the percentage of nondiagnostic segments by one half (P < .01). In patients undergoing treadmill stress echo, harmonic imaging offers a clinically significant improvement in endocardial visualization.

Original languageEnglish (US)
Pages (from-to)559-563
Number of pages5
JournalJournal of the American Society of Echocardiography
Issue number7
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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