Abstract
The synaptic transmission and intrinsic membrane properties of spiny neurons in rat neostriatum were studied after unilateral dopamine depletion using in vivo intracellular recording and staining techniques. Two to four weeks after dopamine denervation, the spontaneous firing rate of spiny neurons increased and the spontaneous membrane potential fluctuation stayed at a more depolarized state for longer periods of time. The amplitude of cortically evoked initial excitatory postsynaptic potentials increased and a late excitatory postsynaptic potential that was occasionally found in control neurons was elicited from 23% of spiny neurons after dopamine denervation. No significant changes in intrinsic membrane properties of spiny neurons were observed after dopamine denervation. These results suggest that dopamine inhibits excitatory synaptic transmission of spiny neurons in naïve animals.
| Original language | English |
|---|---|
| Pages (from-to) | 201-205 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 308 |
| Issue number | 3 |
| DOIs | |
| State | Published - Aug 10 2001 |
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Keywords
- Dopamine
- Excitatory synaptic transmission
- Intracellular recordings
- Spiny neuron
- Striatum
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Enhanced excitatory synaptic transmission in spiny neurons of rat striatum after unilateral dopamine denervation. / Pang, Zhiping; Ling, Guang Y.; Gajendiran, Mahadevan; Xu, Zao C.
In: Neuroscience Letters, Vol. 308, No. 3, 10.08.2001, p. 201-205.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Enhanced excitatory synaptic transmission in spiny neurons of rat striatum after unilateral dopamine denervation
AU - Pang, Zhiping
AU - Ling, Guang Y.
AU - Gajendiran, Mahadevan
AU - Xu, Zao C.
PY - 2001/8/10
Y1 - 2001/8/10
N2 - The synaptic transmission and intrinsic membrane properties of spiny neurons in rat neostriatum were studied after unilateral dopamine depletion using in vivo intracellular recording and staining techniques. Two to four weeks after dopamine denervation, the spontaneous firing rate of spiny neurons increased and the spontaneous membrane potential fluctuation stayed at a more depolarized state for longer periods of time. The amplitude of cortically evoked initial excitatory postsynaptic potentials increased and a late excitatory postsynaptic potential that was occasionally found in control neurons was elicited from 23% of spiny neurons after dopamine denervation. No significant changes in intrinsic membrane properties of spiny neurons were observed after dopamine denervation. These results suggest that dopamine inhibits excitatory synaptic transmission of spiny neurons in naïve animals.
AB - The synaptic transmission and intrinsic membrane properties of spiny neurons in rat neostriatum were studied after unilateral dopamine depletion using in vivo intracellular recording and staining techniques. Two to four weeks after dopamine denervation, the spontaneous firing rate of spiny neurons increased and the spontaneous membrane potential fluctuation stayed at a more depolarized state for longer periods of time. The amplitude of cortically evoked initial excitatory postsynaptic potentials increased and a late excitatory postsynaptic potential that was occasionally found in control neurons was elicited from 23% of spiny neurons after dopamine denervation. No significant changes in intrinsic membrane properties of spiny neurons were observed after dopamine denervation. These results suggest that dopamine inhibits excitatory synaptic transmission of spiny neurons in naïve animals.
KW - Dopamine
KW - Excitatory synaptic transmission
KW - Intracellular recordings
KW - Spiny neuron
KW - Striatum
UR - http://www.scopus.com/inward/record.url?scp=0035839154&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035839154&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(01)02031-6
DO - 10.1016/S0304-3940(01)02031-6
M3 - Article
C2 - 11479023
AN - SCOPUS:0035839154
VL - 308
SP - 201
EP - 205
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -