Enhanced excitatory synaptic transmission in spiny neurons of rat striatum after unilateral dopamine denervation

Zhiping Pang, Guang Y. Ling, Mahadevan Gajendiran, Zao C. Xu

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The synaptic transmission and intrinsic membrane properties of spiny neurons in rat neostriatum were studied after unilateral dopamine depletion using in vivo intracellular recording and staining techniques. Two to four weeks after dopamine denervation, the spontaneous firing rate of spiny neurons increased and the spontaneous membrane potential fluctuation stayed at a more depolarized state for longer periods of time. The amplitude of cortically evoked initial excitatory postsynaptic potentials increased and a late excitatory postsynaptic potential that was occasionally found in control neurons was elicited from 23% of spiny neurons after dopamine denervation. No significant changes in intrinsic membrane properties of spiny neurons were observed after dopamine denervation. These results suggest that dopamine inhibits excitatory synaptic transmission of spiny neurons in naïve animals.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalNeuroscience Letters
Volume308
Issue number3
DOIs
StatePublished - Aug 10 2001

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Denervation
Synaptic Transmission
Dopamine
Neurons
Excitatory Postsynaptic Potentials
Neostriatum
Membranes
Dopaminergic Neurons
Membrane Potentials
Staining and Labeling

Keywords

  • Dopamine
  • Excitatory synaptic transmission
  • Intracellular recordings
  • Spiny neuron
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Enhanced excitatory synaptic transmission in spiny neurons of rat striatum after unilateral dopamine denervation. / Pang, Zhiping; Ling, Guang Y.; Gajendiran, Mahadevan; Xu, Zao C.

In: Neuroscience Letters, Vol. 308, No. 3, 10.08.2001, p. 201-205.

Research output: Contribution to journalArticle

Pang, Zhiping ; Ling, Guang Y. ; Gajendiran, Mahadevan ; Xu, Zao C. / Enhanced excitatory synaptic transmission in spiny neurons of rat striatum after unilateral dopamine denervation. In: Neuroscience Letters. 2001 ; Vol. 308, No. 3. pp. 201-205.
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