Enhanced modeling of the immune system to incorporate natural killer cells and memory

Ann Rundell, Harm HogenEsch, Ray DeCarlo

Research output: Contribution to journalConference article

7 Scopus citations


This paper describes modifications to a 13th order nonlinear differential-delay model (developed by Marchuk, Petrov, Bocharov and Romanyukha) of the immune response to a viral influenza infection. These modifications (i) reflect recent physiological understanding of immunologic processes, (ii) clarify variable definitions, (iii) incorporate B and T memory cell development, and (iv) add the effect of natural killer cells. The model is simulated to show consistency with current theories and understandings in the literature.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalProceedings of the American Control Conference
StatePublished - Jan 1 1995
EventProceedings of the 1995 American Control Conference. Part 1 (of 6) - Seattle, WA, USA
Duration: Jun 21 1995Jun 23 1995


ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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