Enhanced pulmonary toxicity with bleomycin and radiotherapy in oat cell lung cancer

Lawrence Einhorn, M. Krause, N. Hornback, B. Furnas

Research output: Contribution to journalArticle

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Abstract

In a recently completed study, combination chemotherapy consisting of bleomycin, adriamycin, cyclophosphamide, and vincristine was given to 29 patients with oat cell lung cancer. There were no cases of pulmonary fibrosis in these 29 patients. Although several of these patients had prior radiotherapy, none had concomitant radiotherapy and chemotherapy. This same four drug chemotherapy regimen was combined with concomitant radiotherapy in 13 patients with oat cell lung cancer. There were three cases of fatal pulmonary fibrosis and two other cases of clinically significant pulmonary fibrosis. All five cases of pulmonary fibrosis occurred several weeks after completion of a six week course of bleomycin (total dosage 90 units). It is concluded that bleomycin cannot be safely administered while patients are receiving radiotherapy to the lung.

Original languageEnglish
Pages (from-to)2414-2416
Number of pages3
JournalCancer
Volume37
Issue number5
StatePublished - 1976

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Small Cell Lung Carcinoma
Pulmonary Fibrosis
Radiotherapy
Bleomycin
Lung
Drug Therapy
Vincristine
Combination Drug Therapy
Doxorubicin
Cyclophosphamide
indium-bleomycin
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Einhorn, L., Krause, M., Hornback, N., & Furnas, B. (1976). Enhanced pulmonary toxicity with bleomycin and radiotherapy in oat cell lung cancer. Cancer, 37(5), 2414-2416.

Enhanced pulmonary toxicity with bleomycin and radiotherapy in oat cell lung cancer. / Einhorn, Lawrence; Krause, M.; Hornback, N.; Furnas, B.

In: Cancer, Vol. 37, No. 5, 1976, p. 2414-2416.

Research output: Contribution to journalArticle

Einhorn, L, Krause, M, Hornback, N & Furnas, B 1976, 'Enhanced pulmonary toxicity with bleomycin and radiotherapy in oat cell lung cancer', Cancer, vol. 37, no. 5, pp. 2414-2416.
Einhorn, Lawrence ; Krause, M. ; Hornback, N. ; Furnas, B. / Enhanced pulmonary toxicity with bleomycin and radiotherapy in oat cell lung cancer. In: Cancer. 1976 ; Vol. 37, No. 5. pp. 2414-2416.
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