Enhanced T Cell Migration to Sites of Microscopic CNS Disease: Complementary Treatments Evaluated by 2‐ and 3‐D Image Analysis

Lois A. Lampson, Anthony Chen, Alexander Vortmeyer, Andrew E. Sloan, Zoher Ghogawala, Lorence Kim

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Novel therapies are being developed to attack tumour or other abnormal cells within the brain. A general problem is the need for delivery to sites of microscopic disease. Leukocytes offer an attractive solution; they are able to both move through tissue and recognize abnormal targets. Leukocytes may act as effectors, or as vehicles for drugs, retroviral vectors or other agents. Here, we illustrate complementary ways of enhancing leukocyte migration to sites of microscopic central nervous system (CNS) disease. Enhanced T cell migration to sites of disseminated tumour is used as the example. Computer‐assisted image analysis is used to evaluate migration patterns in 2 and 3 dimensions. Shared regulatory features in the migration of tumour and responding cells, and the opportunities and questions they imply, are discussed.

Original languageEnglish (US)
Pages (from-to)125-134
Number of pages10
JournalBrain Pathology
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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Central Nervous System Diseases
Cell Movement
Leukocytes
T-Lymphocytes
Neoplasms
Brain
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

Cite this

Enhanced T Cell Migration to Sites of Microscopic CNS Disease : Complementary Treatments Evaluated by 2‐ and 3‐D Image Analysis. / Lampson, Lois A.; Chen, Anthony; Vortmeyer, Alexander; Sloan, Andrew E.; Ghogawala, Zoher; Kim, Lorence.

In: Brain Pathology, Vol. 4, No. 2, 01.01.1994, p. 125-134.

Research output: Contribution to journalArticle

Lampson, Lois A. ; Chen, Anthony ; Vortmeyer, Alexander ; Sloan, Andrew E. ; Ghogawala, Zoher ; Kim, Lorence. / Enhanced T Cell Migration to Sites of Microscopic CNS Disease : Complementary Treatments Evaluated by 2‐ and 3‐D Image Analysis. In: Brain Pathology. 1994 ; Vol. 4, No. 2. pp. 125-134.
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