Groups of 10 mice were given doses of saline or 6, 8 or 10 mg/kg of diphenylhydantoin i.p. At either 10, 20 or 30 min later they were exposed to a supramaximal electroshock. Some mice were also placed on a shaker and shaken at either 3.1 or 4.6 Hz following drug administration. This shaking caused a more rapid onset and more intense anticonvulsant effect. The enhancement was much greater in the animals exposed to the higher intensity stress. Premedication with either phenoxybenzamine and/or propranolol 30 min before administration of the diphenylhydantoin diminished or even reversed the enhancement of the anticonvulsant activity caused by the higher intensity stress. It was concluded that the stress induced enhancement of diphenylhydantoin's anticonvulsant activity involved activation of the sympathetic nervous system, likely release of epinephrine from the adrenal medulla. The combination of phenoxybenzamine, higher intensity shaking and electroshock was lethal to many of the animals.
|Original language||English (US)|
|Number of pages||8|
|Journal||Archives Internationales de Pharmacodynamie et de Therapie|
|State||Published - Dec 1 1974|
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