Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yung Ning Yang, Kai ming Chou, Wen Yu Pan, Yih wen Chen, Tsui Chun Tsou, Ssu Ching Yeh, Chun Hei Antonio Cheung, Li Tzong Chen, Jang Yang Chang

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Abstract

D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.

Original languageEnglish (US)
Pages (from-to)110-118
Number of pages9
JournalCancer Letters
Volume309
Issue number1
DOIs
StatePublished - Oct 1 2011

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Keywords

  • DNA double strand breaks
  • Drug resistance
  • Selenophene

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Yang, Y. N., Chou, K. M., Pan, W. Y., Chen, Y. W., Tsou, T. C., Yeh, S. C., Cheung, C. H. A., Chen, L. T., & Chang, J. Y. (2011). Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036. Cancer Letters, 309(1), 110-118. https://doi.org/10.1016/j.canlet.2011.05.023