Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036

Yung Ning Yang, Kai ming Chou, Wen Yu Pan, Yih wen Chen, Tsui Chun Tsou, Ssu Ching Yeh, Chun Hei Antonio Cheung, Li Tzong Chen, Jang Yang Chang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

D-501036 is a promising anti-cancer compound that exhibits potent anti-proliferative activity against various types of human cancers through the induction of double strand DNA breaks. To determine drug resistance mechanism related to this class of DNA-damaging agents, a KB-derived D-501036-resistant cell line (S4) was established. Results showed that S4 cells exhibit enhanced DNA rejoining ability as compare to KB cells, through up-regulation of the non-homologous end joining activity. In conclusion, enhancement of NHEJ activity plays important role in the development of D-501036-resistance and targeting NHEJ-related molecules maybe able to overcome drug resistance to DNA damaging agents.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalCancer Letters
Volume309
Issue number1
DOIs
StatePublished - Oct 1 2011

Fingerprint

DNA Repair
Drug Resistance
DNA
KB Cells
Neoplasms
Double-Stranded DNA Breaks
Up-Regulation
Cell Line
2,5-bis(5-hydroxymethyl-2-selenienyl)-3-hydroxymethyl-N-methylpyrrole

Keywords

  • DNA double strand breaks
  • Drug resistance
  • Selenophene

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036. / Yang, Yung Ning; Chou, Kai ming; Pan, Wen Yu; Chen, Yih wen; Tsou, Tsui Chun; Yeh, Ssu Ching; Cheung, Chun Hei Antonio; Chen, Li Tzong; Chang, Jang Yang.

In: Cancer Letters, Vol. 309, No. 1, 01.10.2011, p. 110-118.

Research output: Contribution to journalArticle

Yang, YN, Chou, KM, Pan, WY, Chen, YW, Tsou, TC, Yeh, SC, Cheung, CHA, Chen, LT & Chang, JY 2011, 'Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036', Cancer Letters, vol. 309, no. 1, pp. 110-118. https://doi.org/10.1016/j.canlet.2011.05.023
Yang, Yung Ning ; Chou, Kai ming ; Pan, Wen Yu ; Chen, Yih wen ; Tsou, Tsui Chun ; Yeh, Ssu Ching ; Cheung, Chun Hei Antonio ; Chen, Li Tzong ; Chang, Jang Yang. / Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036. In: Cancer Letters. 2011 ; Vol. 309, No. 1. pp. 110-118.
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