Enhancing predicted fluoride varnish efficacy and post-treatment compliance by means of calcium-containing gummy bears

Frank Lippert, L. Al Dehailan, G. A. Castiblanco, A. A. Tagelsir, C. Buckley, G. J. Eckert

Research output: Contribution to journalArticle

Abstract

Objectives: This study determined whether consumption of calcium-containing gummies prior to fluoride varnish application enhances plaque fluoride retention and compliance with post-varnish application instructions. Methods: The present study followed a multi-center, parallel, randomized, and laboratory analyst-blind design. Following IRB approval, parent consent and child assent, 44 subjects (7–12 years), were randomized to either gummy or no-gummy study groups. A baseline plaque sample was obtained after a wash-out period. Fluoride varnish (5% NaF) was applied; subjects in the gummy group received two calcium-containing gummies prior to varnish application. Subjects were given two questionnaires to complete (subject and parent) to investigate adherence to post-treatment instructions. Three days later, a second plaque sample was obtained. Plaque was analyzed for plaque fluid and solid fluoride concentrations. Fluoride data were analyzed using Wilcoxon Rank Sum tests, questionnaire data using Pearson chi-square tests. Results: Plaque fluid fluoride did not change pre- to post-treatment in the gummy group (mean ± sd: 8.8 ± 5.7 μmol/l vs. 10.0 ± 6.3 μmol/l; p = 0.265) or in the no-gummy group (8.1 ± 4.4 μmol/l vs. 16.1 ± 20.0 μmol/l; p = 0.058). Groups were not different for plaque fluid fluoride pre-treatment (p = 1.000), post-treatment (p = 0.904), or change (p = 0.904). Plaque solid fluoride did not change pre- to post-treatment in the gummy group (0.89 ± 1.10 μmol/g vs. 1.37 ± 1.77 μmol/g; p = 0.073) or in the no-gummy group (0.68 ± 0.77 μmol/g vs. 2.01 ± 5.00 μmol/g; p = 0.190). Groups were not different for plaque solid fluoride pre-treatment (p = 1.000), post-treatment (p = 0.466), or change (p = 0.874). No significant differences were found between groups for questionnaire responses. Conclusion: This study failed to demonstrate an effect of calcium-containing gummies in enhancing plaque fluoride retention. Clinical significance: The consumption of calcium-containing gummies prior to fluoride varnish application does not promote greater intra-oral fluoride retention or better adherence to post-treatment instructions.

Original languageEnglish (US)
JournalJournal of Dentistry
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Topical Fluorides
Fluorides
Compliance
Calcium
Paint
Nonparametric Statistics
Therapeutics
Research Ethics Committees
Chi-Square Distribution

Keywords

  • Calcium
  • Caries
  • Fluoride varnish
  • Gummies
  • Plaque

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Enhancing predicted fluoride varnish efficacy and post-treatment compliance by means of calcium-containing gummy bears. / Lippert, Frank; Al Dehailan, L.; Castiblanco, G. A.; Tagelsir, A. A.; Buckley, C.; Eckert, G. J.

In: Journal of Dentistry, 01.01.2018.

Research output: Contribution to journalArticle

Lippert, Frank ; Al Dehailan, L. ; Castiblanco, G. A. ; Tagelsir, A. A. ; Buckley, C. ; Eckert, G. J. / Enhancing predicted fluoride varnish efficacy and post-treatment compliance by means of calcium-containing gummy bears. In: Journal of Dentistry. 2018.
@article{527cb8409f7b41bfa9e8852a3932e668,
title = "Enhancing predicted fluoride varnish efficacy and post-treatment compliance by means of calcium-containing gummy bears",
abstract = "Objectives: This study determined whether consumption of calcium-containing gummies prior to fluoride varnish application enhances plaque fluoride retention and compliance with post-varnish application instructions. Methods: The present study followed a multi-center, parallel, randomized, and laboratory analyst-blind design. Following IRB approval, parent consent and child assent, 44 subjects (7–12 years), were randomized to either gummy or no-gummy study groups. A baseline plaque sample was obtained after a wash-out period. Fluoride varnish (5{\%} NaF) was applied; subjects in the gummy group received two calcium-containing gummies prior to varnish application. Subjects were given two questionnaires to complete (subject and parent) to investigate adherence to post-treatment instructions. Three days later, a second plaque sample was obtained. Plaque was analyzed for plaque fluid and solid fluoride concentrations. Fluoride data were analyzed using Wilcoxon Rank Sum tests, questionnaire data using Pearson chi-square tests. Results: Plaque fluid fluoride did not change pre- to post-treatment in the gummy group (mean ± sd: 8.8 ± 5.7 μmol/l vs. 10.0 ± 6.3 μmol/l; p = 0.265) or in the no-gummy group (8.1 ± 4.4 μmol/l vs. 16.1 ± 20.0 μmol/l; p = 0.058). Groups were not different for plaque fluid fluoride pre-treatment (p = 1.000), post-treatment (p = 0.904), or change (p = 0.904). Plaque solid fluoride did not change pre- to post-treatment in the gummy group (0.89 ± 1.10 μmol/g vs. 1.37 ± 1.77 μmol/g; p = 0.073) or in the no-gummy group (0.68 ± 0.77 μmol/g vs. 2.01 ± 5.00 μmol/g; p = 0.190). Groups were not different for plaque solid fluoride pre-treatment (p = 1.000), post-treatment (p = 0.466), or change (p = 0.874). No significant differences were found between groups for questionnaire responses. Conclusion: This study failed to demonstrate an effect of calcium-containing gummies in enhancing plaque fluoride retention. Clinical significance: The consumption of calcium-containing gummies prior to fluoride varnish application does not promote greater intra-oral fluoride retention or better adherence to post-treatment instructions.",
keywords = "Calcium, Caries, Fluoride varnish, Gummies, Plaque",
author = "Frank Lippert and {Al Dehailan}, L. and Castiblanco, {G. A.} and Tagelsir, {A. A.} and C. Buckley and Eckert, {G. J.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.jdent.2018.03.015",
language = "English (US)",
journal = "Journal of Dentistry",
issn = "0300-5712",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Enhancing predicted fluoride varnish efficacy and post-treatment compliance by means of calcium-containing gummy bears

AU - Lippert, Frank

AU - Al Dehailan, L.

AU - Castiblanco, G. A.

AU - Tagelsir, A. A.

AU - Buckley, C.

AU - Eckert, G. J.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives: This study determined whether consumption of calcium-containing gummies prior to fluoride varnish application enhances plaque fluoride retention and compliance with post-varnish application instructions. Methods: The present study followed a multi-center, parallel, randomized, and laboratory analyst-blind design. Following IRB approval, parent consent and child assent, 44 subjects (7–12 years), were randomized to either gummy or no-gummy study groups. A baseline plaque sample was obtained after a wash-out period. Fluoride varnish (5% NaF) was applied; subjects in the gummy group received two calcium-containing gummies prior to varnish application. Subjects were given two questionnaires to complete (subject and parent) to investigate adherence to post-treatment instructions. Three days later, a second plaque sample was obtained. Plaque was analyzed for plaque fluid and solid fluoride concentrations. Fluoride data were analyzed using Wilcoxon Rank Sum tests, questionnaire data using Pearson chi-square tests. Results: Plaque fluid fluoride did not change pre- to post-treatment in the gummy group (mean ± sd: 8.8 ± 5.7 μmol/l vs. 10.0 ± 6.3 μmol/l; p = 0.265) or in the no-gummy group (8.1 ± 4.4 μmol/l vs. 16.1 ± 20.0 μmol/l; p = 0.058). Groups were not different for plaque fluid fluoride pre-treatment (p = 1.000), post-treatment (p = 0.904), or change (p = 0.904). Plaque solid fluoride did not change pre- to post-treatment in the gummy group (0.89 ± 1.10 μmol/g vs. 1.37 ± 1.77 μmol/g; p = 0.073) or in the no-gummy group (0.68 ± 0.77 μmol/g vs. 2.01 ± 5.00 μmol/g; p = 0.190). Groups were not different for plaque solid fluoride pre-treatment (p = 1.000), post-treatment (p = 0.466), or change (p = 0.874). No significant differences were found between groups for questionnaire responses. Conclusion: This study failed to demonstrate an effect of calcium-containing gummies in enhancing plaque fluoride retention. Clinical significance: The consumption of calcium-containing gummies prior to fluoride varnish application does not promote greater intra-oral fluoride retention or better adherence to post-treatment instructions.

AB - Objectives: This study determined whether consumption of calcium-containing gummies prior to fluoride varnish application enhances plaque fluoride retention and compliance with post-varnish application instructions. Methods: The present study followed a multi-center, parallel, randomized, and laboratory analyst-blind design. Following IRB approval, parent consent and child assent, 44 subjects (7–12 years), were randomized to either gummy or no-gummy study groups. A baseline plaque sample was obtained after a wash-out period. Fluoride varnish (5% NaF) was applied; subjects in the gummy group received two calcium-containing gummies prior to varnish application. Subjects were given two questionnaires to complete (subject and parent) to investigate adherence to post-treatment instructions. Three days later, a second plaque sample was obtained. Plaque was analyzed for plaque fluid and solid fluoride concentrations. Fluoride data were analyzed using Wilcoxon Rank Sum tests, questionnaire data using Pearson chi-square tests. Results: Plaque fluid fluoride did not change pre- to post-treatment in the gummy group (mean ± sd: 8.8 ± 5.7 μmol/l vs. 10.0 ± 6.3 μmol/l; p = 0.265) or in the no-gummy group (8.1 ± 4.4 μmol/l vs. 16.1 ± 20.0 μmol/l; p = 0.058). Groups were not different for plaque fluid fluoride pre-treatment (p = 1.000), post-treatment (p = 0.904), or change (p = 0.904). Plaque solid fluoride did not change pre- to post-treatment in the gummy group (0.89 ± 1.10 μmol/g vs. 1.37 ± 1.77 μmol/g; p = 0.073) or in the no-gummy group (0.68 ± 0.77 μmol/g vs. 2.01 ± 5.00 μmol/g; p = 0.190). Groups were not different for plaque solid fluoride pre-treatment (p = 1.000), post-treatment (p = 0.466), or change (p = 0.874). No significant differences were found between groups for questionnaire responses. Conclusion: This study failed to demonstrate an effect of calcium-containing gummies in enhancing plaque fluoride retention. Clinical significance: The consumption of calcium-containing gummies prior to fluoride varnish application does not promote greater intra-oral fluoride retention or better adherence to post-treatment instructions.

KW - Calcium

KW - Caries

KW - Fluoride varnish

KW - Gummies

KW - Plaque

UR - http://www.scopus.com/inward/record.url?scp=85045087322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045087322&partnerID=8YFLogxK

U2 - 10.1016/j.jdent.2018.03.015

DO - 10.1016/j.jdent.2018.03.015

M3 - Article

C2 - 29609017

AN - SCOPUS:85045087322

JO - Journal of Dentistry

JF - Journal of Dentistry

SN - 0300-5712

ER -