ENIGMA and the individual

Predicting factors that affect the brain in 35 countries worldwide

Paul M. Thompson, Ole A. Andreassen, Alejandro Arias-Vasquez, Carrie E. Bearden, Premika S. Boedhoe, Rachel M. Brouwer, Randy L. Buckner, Jan K. Buitelaar, Kazima B. Bulayeva, Dara M. Cannon, Ronald A. Cohen, Patricia J. Conrod, Anders M. Dale, Ian J. Deary, Emily L. Dennis, Marcel A. de Reus, Sylvane Desrivieres, Danai Dima, Gary Donohoe, Simon E. Fisher & 51 others Jean Paul Fouche, Clyde Francks, Sophia Frangou, Barbara Franke, Habib Ganjgahi, Hugh Garavan, David C. Glahn, Hans J. Grabe, Tulio Guadalupe, Boris A. Gutman, Ryota Hashimoto, Derrek P. Hibar, Dominic Holland, Martine Hoogman, Hilleke E Hulshoff Pol, Norbert Hosten, Neda Jahanshad, Sinead Kelly, Peter Kochunov, William S. Kremen, Phil H. Lee, Scott Mackey, Nicholas G. Martin, Bernard Mazoyer, Colm McDonald, Sarah E. Medland, Rajendra A. Morey, Thomas E. Nichols, Tomas Paus, Zdenka Pausova, Lianne Schmaal, Gunter Schumann, Li Shen, Sanjay M. Sisodiya, Dirk J A Smit, Jordan W. Smoller, Dan J. Stein, Jason L. Stein, Roberto Toro, Li Shen, Martijn P. van den Heuvel, Odile L. van den Heuvel, Theo G M van Erp, Daan van Rooij, Dick J. Veltman, Henrik Walter, Yalin Wang, Joanna M. Wardlaw, Christopher D. Whelan, Margaret J. Wright, Jieping Ye

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. In partnership with other consortia including ADNI, CHARGE, IMAGEN and others. 1 1Abbreviations: ADNI, Alzheimer's Disease Neuroimaging Initiative (http://www.adni-info.org); CHARGE, the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (http://www.chargeconsortium.com); IMAGEN, IMAging GENetics Consortium (http://www.imagen-europe.com)., ENIGMA's genomic screens - now numbering over 30,000 MRI scans - have revealed at least 8 genetic loci that affect brain volumes. Downstream of gene findings, ENIGMA has revealed how these individual variants - and genetic variants in general - may affect both the brain and risk for a range of diseases. The ENIGMA consortium is discovering factors that consistently affect brain structure and function that will serve as future predictors linking individual brain scans and genomic data. It is generating vast pools of normative data on brain measures - from tens of thousands of people - that may help detect deviations from normal development or aging in specific groups of subjects. We discuss challenges and opportunities in applying these predictors to individual subjects and new cohorts, as well as lessons we have learned in ENIGMA's efforts so far.

Original languageEnglish (US)
JournalNeuroImage
DOIs
StateAccepted/In press - 2016

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Brain
Neuroimaging
Genetic Loci
Brain Diseases
Schizophrenia
Alzheimer Disease
Epidemiology
Magnetic Resonance Imaging
Depression
Research
Genes

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Thompson, P. M., Andreassen, O. A., Arias-Vasquez, A., Bearden, C. E., Boedhoe, P. S., Brouwer, R. M., ... Ye, J. (Accepted/In press). ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide. NeuroImage. https://doi.org/10.1016/j.neuroimage.2015.11.057

ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide. / Thompson, Paul M.; Andreassen, Ole A.; Arias-Vasquez, Alejandro; Bearden, Carrie E.; Boedhoe, Premika S.; Brouwer, Rachel M.; Buckner, Randy L.; Buitelaar, Jan K.; Bulayeva, Kazima B.; Cannon, Dara M.; Cohen, Ronald A.; Conrod, Patricia J.; Dale, Anders M.; Deary, Ian J.; Dennis, Emily L.; de Reus, Marcel A.; Desrivieres, Sylvane; Dima, Danai; Donohoe, Gary; Fisher, Simon E.; Fouche, Jean Paul; Francks, Clyde; Frangou, Sophia; Franke, Barbara; Ganjgahi, Habib; Garavan, Hugh; Glahn, David C.; Grabe, Hans J.; Guadalupe, Tulio; Gutman, Boris A.; Hashimoto, Ryota; Hibar, Derrek P.; Holland, Dominic; Hoogman, Martine; Pol, Hilleke E Hulshoff; Hosten, Norbert; Jahanshad, Neda; Kelly, Sinead; Kochunov, Peter; Kremen, William S.; Lee, Phil H.; Mackey, Scott; Martin, Nicholas G.; Mazoyer, Bernard; McDonald, Colm; Medland, Sarah E.; Morey, Rajendra A.; Nichols, Thomas E.; Paus, Tomas; Pausova, Zdenka; Schmaal, Lianne; Schumann, Gunter; Shen, Li; Sisodiya, Sanjay M.; Smit, Dirk J A; Smoller, Jordan W.; Stein, Dan J.; Stein, Jason L.; Toro, Roberto; Shen, Li; van den Heuvel, Martijn P.; van den Heuvel, Odile L.; van Erp, Theo G M; van Rooij, Daan; Veltman, Dick J.; Walter, Henrik; Wang, Yalin; Wardlaw, Joanna M.; Whelan, Christopher D.; Wright, Margaret J.; Ye, Jieping.

In: NeuroImage, 2016.

Research output: Contribution to journalArticle

Thompson, PM, Andreassen, OA, Arias-Vasquez, A, Bearden, CE, Boedhoe, PS, Brouwer, RM, Buckner, RL, Buitelaar, JK, Bulayeva, KB, Cannon, DM, Cohen, RA, Conrod, PJ, Dale, AM, Deary, IJ, Dennis, EL, de Reus, MA, Desrivieres, S, Dima, D, Donohoe, G, Fisher, SE, Fouche, JP, Francks, C, Frangou, S, Franke, B, Ganjgahi, H, Garavan, H, Glahn, DC, Grabe, HJ, Guadalupe, T, Gutman, BA, Hashimoto, R, Hibar, DP, Holland, D, Hoogman, M, Pol, HEH, Hosten, N, Jahanshad, N, Kelly, S, Kochunov, P, Kremen, WS, Lee, PH, Mackey, S, Martin, NG, Mazoyer, B, McDonald, C, Medland, SE, Morey, RA, Nichols, TE, Paus, T, Pausova, Z, Schmaal, L, Schumann, G, Shen, L, Sisodiya, SM, Smit, DJA, Smoller, JW, Stein, DJ, Stein, JL, Toro, R, Shen, L, van den Heuvel, MP, van den Heuvel, OL, van Erp, TGM, van Rooij, D, Veltman, DJ, Walter, H, Wang, Y, Wardlaw, JM, Whelan, CD, Wright, MJ & Ye, J 2016, 'ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide', NeuroImage. https://doi.org/10.1016/j.neuroimage.2015.11.057
Thompson, Paul M. ; Andreassen, Ole A. ; Arias-Vasquez, Alejandro ; Bearden, Carrie E. ; Boedhoe, Premika S. ; Brouwer, Rachel M. ; Buckner, Randy L. ; Buitelaar, Jan K. ; Bulayeva, Kazima B. ; Cannon, Dara M. ; Cohen, Ronald A. ; Conrod, Patricia J. ; Dale, Anders M. ; Deary, Ian J. ; Dennis, Emily L. ; de Reus, Marcel A. ; Desrivieres, Sylvane ; Dima, Danai ; Donohoe, Gary ; Fisher, Simon E. ; Fouche, Jean Paul ; Francks, Clyde ; Frangou, Sophia ; Franke, Barbara ; Ganjgahi, Habib ; Garavan, Hugh ; Glahn, David C. ; Grabe, Hans J. ; Guadalupe, Tulio ; Gutman, Boris A. ; Hashimoto, Ryota ; Hibar, Derrek P. ; Holland, Dominic ; Hoogman, Martine ; Pol, Hilleke E Hulshoff ; Hosten, Norbert ; Jahanshad, Neda ; Kelly, Sinead ; Kochunov, Peter ; Kremen, William S. ; Lee, Phil H. ; Mackey, Scott ; Martin, Nicholas G. ; Mazoyer, Bernard ; McDonald, Colm ; Medland, Sarah E. ; Morey, Rajendra A. ; Nichols, Thomas E. ; Paus, Tomas ; Pausova, Zdenka ; Schmaal, Lianne ; Schumann, Gunter ; Shen, Li ; Sisodiya, Sanjay M. ; Smit, Dirk J A ; Smoller, Jordan W. ; Stein, Dan J. ; Stein, Jason L. ; Toro, Roberto ; Shen, Li ; van den Heuvel, Martijn P. ; van den Heuvel, Odile L. ; van Erp, Theo G M ; van Rooij, Daan ; Veltman, Dick J. ; Walter, Henrik ; Wang, Yalin ; Wardlaw, Joanna M. ; Whelan, Christopher D. ; Wright, Margaret J. ; Ye, Jieping. / ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide. In: NeuroImage. 2016.
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abstract = "In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. In partnership with other consortia including ADNI, CHARGE, IMAGEN and others. 1 1Abbreviations: ADNI, Alzheimer's Disease Neuroimaging Initiative (http://www.adni-info.org); CHARGE, the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (http://www.chargeconsortium.com); IMAGEN, IMAging GENetics Consortium (http://www.imagen-europe.com)., ENIGMA's genomic screens - now numbering over 30,000 MRI scans - have revealed at least 8 genetic loci that affect brain volumes. Downstream of gene findings, ENIGMA has revealed how these individual variants - and genetic variants in general - may affect both the brain and risk for a range of diseases. The ENIGMA consortium is discovering factors that consistently affect brain structure and function that will serve as future predictors linking individual brain scans and genomic data. It is generating vast pools of normative data on brain measures - from tens of thousands of people - that may help detect deviations from normal development or aging in specific groups of subjects. We discuss challenges and opportunities in applying these predictors to individual subjects and new cohorts, as well as lessons we have learned in ENIGMA's efforts so far.",
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T2 - Predicting factors that affect the brain in 35 countries worldwide

AU - Thompson, Paul M.

AU - Andreassen, Ole A.

AU - Arias-Vasquez, Alejandro

AU - Bearden, Carrie E.

AU - Boedhoe, Premika S.

AU - Brouwer, Rachel M.

AU - Buckner, Randy L.

AU - Buitelaar, Jan K.

AU - Bulayeva, Kazima B.

AU - Cannon, Dara M.

AU - Cohen, Ronald A.

AU - Conrod, Patricia J.

AU - Dale, Anders M.

AU - Deary, Ian J.

AU - Dennis, Emily L.

AU - de Reus, Marcel A.

AU - Desrivieres, Sylvane

AU - Dima, Danai

AU - Donohoe, Gary

AU - Fisher, Simon E.

AU - Fouche, Jean Paul

AU - Francks, Clyde

AU - Frangou, Sophia

AU - Franke, Barbara

AU - Ganjgahi, Habib

AU - Garavan, Hugh

AU - Glahn, David C.

AU - Grabe, Hans J.

AU - Guadalupe, Tulio

AU - Gutman, Boris A.

AU - Hashimoto, Ryota

AU - Hibar, Derrek P.

AU - Holland, Dominic

AU - Hoogman, Martine

AU - Pol, Hilleke E Hulshoff

AU - Hosten, Norbert

AU - Jahanshad, Neda

AU - Kelly, Sinead

AU - Kochunov, Peter

AU - Kremen, William S.

AU - Lee, Phil H.

AU - Mackey, Scott

AU - Martin, Nicholas G.

AU - Mazoyer, Bernard

AU - McDonald, Colm

AU - Medland, Sarah E.

AU - Morey, Rajendra A.

AU - Nichols, Thomas E.

AU - Paus, Tomas

AU - Pausova, Zdenka

AU - Schmaal, Lianne

AU - Schumann, Gunter

AU - Shen, Li

AU - Sisodiya, Sanjay M.

AU - Smit, Dirk J A

AU - Smoller, Jordan W.

AU - Stein, Dan J.

AU - Stein, Jason L.

AU - Toro, Roberto

AU - Shen, Li

AU - van den Heuvel, Martijn P.

AU - van den Heuvel, Odile L.

AU - van Erp, Theo G M

AU - van Rooij, Daan

AU - Veltman, Dick J.

AU - Walter, Henrik

AU - Wang, Yalin

AU - Wardlaw, Joanna M.

AU - Whelan, Christopher D.

AU - Wright, Margaret J.

AU - Ye, Jieping

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