Enigmatic effect of cellular ATP on fatty acid biosynthesis. Stimulation by moderate decrease and inhibition by increase of cellular ATP

Math J.H. Geelen, Robert A. Harris, Simon G. Van den Bergh

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The cellular ATP concentration was tested for its effect on fatty acid biosynthesis from glucose in hepatocytes. ATP was manipulated by adding increasing concentrations of cycloheximide, amytal, atractyloside, 2,4-dinitrophenol or adenosine. A slight decrease in cellular ATP coincided with a stimulation of fatty acid biosynthesis whereas a further lowering of cellular ATP resulted in a gradual inhibition. Increasing the cellular ATP level by titration with adenosine had the opposite effect. These results are in line with the suggestion that fatty acid biosynthesis from glucose is an energy-yielding process which is stimulated by a moderate drop in cellular ATP.

Original languageEnglish (US)
Pages (from-to)2242-2246
Number of pages5
JournalFEBS Letters
Volume582
Issue number15
DOIs
StatePublished - Jun 25 2008

Keywords

  • 2,4-Dinitrophenol
  • Adenosine
  • Amytal
  • Atractyloside
  • Cellular ATP level
  • Cycloheximide
  • Fatty acid biosynthesis
  • Hepatocytes
  • Short-term control

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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