Enzymatic synthesis of 2-deoxyglucose-containing maltooligosaccharides for tracing the location of glucose absorption from starch digestion

Byung Hoo Lee, Dong Wan Koh, Paul R. Territo, Cheon Seok Park, Bruce R. Hamaker, Sang Ho Yoo

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Abstract The ileal brake mechanism which induces a potentially beneficial slower gastric emptying rate and increased satiety is triggered by macronutrients including glucose from glycemic carbohydrates. For optimization of this diet-induced health benefit, there is the need for a way to determine the location of glucose deposition in the small intestine. Labeled 2-deoxyglucose (2-DG) can be used to trace the location of glucose absorption due to its accumulative property in the small intestine enterocytes. However, because pure glucose, or 2-DG, is directly absorbed in the proximal small intestine, we designed 2-DG containing maltooligosaccharides (2-DG-MOs) that can be used with a mild α-glucosidase inhibitor to attain an analytical method for determining location-specific delivery of glucose and its physiological effect.

Original languageEnglish (US)
Article number9996
Pages (from-to)41-49
Number of pages9
JournalCarbohydrate Polymers
Volume132
DOIs
StatePublished - Jun 30 2015

Keywords

  • 2-Deoxyglucose (2-DG)
  • Amylosucrase
  • Glucose absorption
  • Maltooligosaccharides
  • Mucosal α-glucosidases

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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