Eosinophilic Esophagitis in Children and Adolescents with Abdominal Pain: Comparison with EoE-Dysphagia and Functional Abdominal Pain

Thirumazhisai Gunasekaran, Gautham Prabhakar, Alan Schwartz, Kiranmai Gorla, Sandeep Gupta, James Berman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim. Compare EoE-AP with EoE-D for clinical, endoscopy (EGD), histology and outcomes and also with FAP-N. Method. Symptoms, physical findings, EGD, histology, symptom scores, and treatments were recorded for the three groups. Cluster analysis was done. Results. Dysphagia and abdominal pain were different in numbers but not statistically significant between EoE-AP and EoE-D. EGD, linear furrows, white exudates were more in the EoE-D and both combined were significant (p < 0.05). EoE-D, peak and mean eosinophils (p 0.06) and eosinophilic micro abscesses (p 0.001) were higher. Follow-Up. Based on single symptom, EoE-AP had 30% (p 0. 25) improvement, EoE-D 86% (p < 0.001) and similar with composite score (p 0.57 and <0.001, resp.). Patients who had follow-up, EGD: 42.8% with EoE-AP and 77.8% with EoE-D, showed single symptom improvement and the eosinophil count fell from 38.5/34.6 (peak and mean) to 31.2/30.4 (p 0.70) and from 43.6/40.8 to 25.2/22.8 (p < 0.001), respectively. FAP-N patients had similar symptom improvement like EoE-D. Cluster Analysis. EoE-AP and FAP-N were similar in clinical features and response to treatment, but EoE-D was distinctly different from EoE-AP and FAP-N. Conclusion. Our study demonstrates that EoE-AP and EoE-D have different histology and outcomes. In addition, EoE-AP has clinical features similar to the FAP-N group.

Original languageEnglish (US)
Article number4123692
JournalCanadian Journal of Gastroenterology and Hepatology
Volume2016
DOIs
StatePublished - 2016

Fingerprint

Eosinophilic Esophagitis
Deglutition Disorders
Abdominal Pain
Histology
Eosinophils
Cluster Analysis
Exudates and Transudates
Abscess
Endoscopy
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Eosinophilic Esophagitis in Children and Adolescents with Abdominal Pain : Comparison with EoE-Dysphagia and Functional Abdominal Pain. / Gunasekaran, Thirumazhisai; Prabhakar, Gautham; Schwartz, Alan; Gorla, Kiranmai; Gupta, Sandeep; Berman, James.

In: Canadian Journal of Gastroenterology and Hepatology, Vol. 2016, 4123692, 2016.

Research output: Contribution to journalArticle

@article{3bbd1dab48a845c7b4267c2ad484264a,
title = "Eosinophilic Esophagitis in Children and Adolescents with Abdominal Pain: Comparison with EoE-Dysphagia and Functional Abdominal Pain",
abstract = "Aim. Compare EoE-AP with EoE-D for clinical, endoscopy (EGD), histology and outcomes and also with FAP-N. Method. Symptoms, physical findings, EGD, histology, symptom scores, and treatments were recorded for the three groups. Cluster analysis was done. Results. Dysphagia and abdominal pain were different in numbers but not statistically significant between EoE-AP and EoE-D. EGD, linear furrows, white exudates were more in the EoE-D and both combined were significant (p < 0.05). EoE-D, peak and mean eosinophils (p 0.06) and eosinophilic micro abscesses (p 0.001) were higher. Follow-Up. Based on single symptom, EoE-AP had 30{\%} (p 0. 25) improvement, EoE-D 86{\%} (p < 0.001) and similar with composite score (p 0.57 and <0.001, resp.). Patients who had follow-up, EGD: 42.8{\%} with EoE-AP and 77.8{\%} with EoE-D, showed single symptom improvement and the eosinophil count fell from 38.5/34.6 (peak and mean) to 31.2/30.4 (p 0.70) and from 43.6/40.8 to 25.2/22.8 (p < 0.001), respectively. FAP-N patients had similar symptom improvement like EoE-D. Cluster Analysis. EoE-AP and FAP-N were similar in clinical features and response to treatment, but EoE-D was distinctly different from EoE-AP and FAP-N. Conclusion. Our study demonstrates that EoE-AP and EoE-D have different histology and outcomes. In addition, EoE-AP has clinical features similar to the FAP-N group.",
author = "Thirumazhisai Gunasekaran and Gautham Prabhakar and Alan Schwartz and Kiranmai Gorla and Sandeep Gupta and James Berman",
year = "2016",
doi = "10.1155/2016/4123692",
language = "English (US)",
volume = "2016",
journal = "Canadian Journal of Gastroenterology and Hepatology",
issn = "2291-2789",
publisher = "Pulsus Group Inc.",

}

TY - JOUR

T1 - Eosinophilic Esophagitis in Children and Adolescents with Abdominal Pain

T2 - Comparison with EoE-Dysphagia and Functional Abdominal Pain

AU - Gunasekaran, Thirumazhisai

AU - Prabhakar, Gautham

AU - Schwartz, Alan

AU - Gorla, Kiranmai

AU - Gupta, Sandeep

AU - Berman, James

PY - 2016

Y1 - 2016

N2 - Aim. Compare EoE-AP with EoE-D for clinical, endoscopy (EGD), histology and outcomes and also with FAP-N. Method. Symptoms, physical findings, EGD, histology, symptom scores, and treatments were recorded for the three groups. Cluster analysis was done. Results. Dysphagia and abdominal pain were different in numbers but not statistically significant between EoE-AP and EoE-D. EGD, linear furrows, white exudates were more in the EoE-D and both combined were significant (p < 0.05). EoE-D, peak and mean eosinophils (p 0.06) and eosinophilic micro abscesses (p 0.001) were higher. Follow-Up. Based on single symptom, EoE-AP had 30% (p 0. 25) improvement, EoE-D 86% (p < 0.001) and similar with composite score (p 0.57 and <0.001, resp.). Patients who had follow-up, EGD: 42.8% with EoE-AP and 77.8% with EoE-D, showed single symptom improvement and the eosinophil count fell from 38.5/34.6 (peak and mean) to 31.2/30.4 (p 0.70) and from 43.6/40.8 to 25.2/22.8 (p < 0.001), respectively. FAP-N patients had similar symptom improvement like EoE-D. Cluster Analysis. EoE-AP and FAP-N were similar in clinical features and response to treatment, but EoE-D was distinctly different from EoE-AP and FAP-N. Conclusion. Our study demonstrates that EoE-AP and EoE-D have different histology and outcomes. In addition, EoE-AP has clinical features similar to the FAP-N group.

AB - Aim. Compare EoE-AP with EoE-D for clinical, endoscopy (EGD), histology and outcomes and also with FAP-N. Method. Symptoms, physical findings, EGD, histology, symptom scores, and treatments were recorded for the three groups. Cluster analysis was done. Results. Dysphagia and abdominal pain were different in numbers but not statistically significant between EoE-AP and EoE-D. EGD, linear furrows, white exudates were more in the EoE-D and both combined were significant (p < 0.05). EoE-D, peak and mean eosinophils (p 0.06) and eosinophilic micro abscesses (p 0.001) were higher. Follow-Up. Based on single symptom, EoE-AP had 30% (p 0. 25) improvement, EoE-D 86% (p < 0.001) and similar with composite score (p 0.57 and <0.001, resp.). Patients who had follow-up, EGD: 42.8% with EoE-AP and 77.8% with EoE-D, showed single symptom improvement and the eosinophil count fell from 38.5/34.6 (peak and mean) to 31.2/30.4 (p 0.70) and from 43.6/40.8 to 25.2/22.8 (p < 0.001), respectively. FAP-N patients had similar symptom improvement like EoE-D. Cluster Analysis. EoE-AP and FAP-N were similar in clinical features and response to treatment, but EoE-D was distinctly different from EoE-AP and FAP-N. Conclusion. Our study demonstrates that EoE-AP and EoE-D have different histology and outcomes. In addition, EoE-AP has clinical features similar to the FAP-N group.

UR - http://www.scopus.com/inward/record.url?scp=84984690301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984690301&partnerID=8YFLogxK

U2 - 10.1155/2016/4123692

DO - 10.1155/2016/4123692

M3 - Article

C2 - 27610357

AN - SCOPUS:84984690301

VL - 2016

JO - Canadian Journal of Gastroenterology and Hepatology

JF - Canadian Journal of Gastroenterology and Hepatology

SN - 2291-2789

M1 - 4123692

ER -