Eosinophilic esophagitis in cystic fibrosis: A case series and review of the literature

Jennifer L. Goralski, Daniel M. Lercher, Stephanie Davis, Evan S. Dellon

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Patients with cystic fibrosis (CF) frequently experience gastrointestinal symptoms including nausea, emesis, malnutrition and indigestion; diseases such as gastroesophageal reflux disease (GERD), distal intestinal obstructive syndrome, and cholelithiasis are commonly implicated. We have recently diagnosed eosinophilic esophagitis (EoE) in three patients with CF. EoE is a TH-2 driven, allergen-mediated disease which causes esophageal eosinophilia and presents with symptoms of nausea, feeding intolerance, regurgitation, and dysphagia. EoE is diagnosed when esophageal biopsies reveal greater than 15 eosinophils per high power field in the setting of the appropriate clinical scenario and after exclusion of other causes of esophageal eosinophilia. Although described with increasing frequently in the gastrointestinal literature, there have been no prior cases documenting the co-existence of EoE and CF. We speculate that this is related to lack of familiarity with EoE symptoms by CF providers. We present three patients with CF diagnosed with EoE and review the current literature regarding diagnosis and management, focusing on management issues in patients with CF.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalJournal of Cystic Fibrosis
Volume12
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Eosinophilic Esophagitis
Cystic Fibrosis
Eosinophilia
Nausea
Cholelithiasis
Dyspepsia
Deglutition Disorders
Gastroesophageal Reflux
Eosinophils
Malnutrition
Allergens
Vomiting
Biopsy

Keywords

  • Allergy
  • Disease
  • Endoscopy
  • Eosinophilic esophagitis
  • Eosinophils
  • Gastroesophageal reflux
  • Gastrointestinal symptoms

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Eosinophilic esophagitis in cystic fibrosis : A case series and review of the literature. / Goralski, Jennifer L.; Lercher, Daniel M.; Davis, Stephanie; Dellon, Evan S.

In: Journal of Cystic Fibrosis, Vol. 12, No. 1, 01.2013, p. 9-14.

Research output: Contribution to journalArticle

Goralski, Jennifer L. ; Lercher, Daniel M. ; Davis, Stephanie ; Dellon, Evan S. / Eosinophilic esophagitis in cystic fibrosis : A case series and review of the literature. In: Journal of Cystic Fibrosis. 2013 ; Vol. 12, No. 1. pp. 9-14.
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